TRANSPLANTATION OF AUTOLOGOUS BONE MARROW MESENCHYMAL STEM CELLS WITH PLATELET-RICH PLASMA ACCELERATE DISTRACTION OSTEOGENESIS IN A CANINE MODEL

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DEHGHAN MOHAMMAD MEHDI; BAGHABAN ESLAMINEJAD MOHAMADREZA; MOTALLEBIZADEH NADER; ASHRAFI HALAN JAVAD; TAGIYAR LEILA; SOROORI SARANG; NIKMAHZAR AGBIBI; PEDRAM MIRSEPEHR; SHAHVERDI ABDOLHOSSEIN; KAZEMI MEHRJERDI HOSSEIN; IZADI SADRA

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Journal: Cell Journal (Yakhteh) Year:2015 | Volume:17 | Issue:2 Page(s): 243-252

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Title

TRANSPLANTATION OF AUTOLOGOUS BONE MARROW MESENCHYMAL STEM CELLS WITH PLATELET-RICH PLASMA ACCELERATE DISTRACTION OSTEOGENESIS IN A CANINE MODEL

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Keywords

DISTRACTION OSTEOGENESIS

BONE LENGTHENING

MESENCHYMAL STEM CELLS

AUTOLOGOUS TRANSPLANTATION

PLATELET-RICH PLASMA

Abstract

Objective: DISTRACTION OSTEOGENESIS (DO) is a surgical procedure used to generate large volumes of new bone for limb lengthening.Materials and Methods: In this animal experimental study, a 30% lengthening of the left tibia (mean distraction distance: 60.8 mm) was performed in ten adult male dogs by callus distraction after osteotomy and application of an Ilizarov fixator. Distraction was started on postoperative day seven with a distraction rate of 0.5 mm twice per day and carried out at a rate of 1.5 mm per day until the end of the study. Autologous bone marrow MESENCHYMAL STEM CELLS (BM-MSCs) and PLATELET-RICH PLASMA (PRP) as the treatment group (n=5) or PRP alone (control group, n=5) were injected into the distracted callus at the middle and end of the distraction period. At the end of the consolidation period, the dogs were sacrificed after which computerized tomography (CT) and histomorphometric evaluations were performed.Results: Radiographic evaluationsrevealed that the amount and quality of callus formations were significantly higher in the treatment group (P<0.05). As measured by CT scan, the healing parametersin dogs of the treatment group were significantly greater (P<0.05). New bone formation in the treatment group was significantly higher (P<0.05).Conclusion: The present study showed that the transplantation of BM-MSCs positively affects early bony consolidation in DO. The use of MSCs might allow a shortened period of consolidation and therefore permit earlier device removal.

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APA: Copy

DEHGHAN, MOHAMMAD MEHDI, BAGHABAN ESLAMINEJAD, MOHAMADREZA, MOTALLEBIZADEH, NADER, ASHRAFI HALAN, JAVAD, TAGIYAR, LEILA, SOROORI, SARANG, NIKMAHZAR, AGBIBI, PEDRAM, MIRSEPEHR, SHAHVERDI, ABDOLHOSSEIN, KAZEMI MEHRJERDI, HOSSEIN, & IZADI, SADRA. (2015). TRANSPLANTATION OF AUTOLOGOUS BONE MARROW MESENCHYMAL STEM CELLS WITH PLATELET-RICH PLASMA ACCELERATE DISTRACTION OSTEOGENESIS IN A CANINE MODEL. CELL JOURNAL (YAKHTEH), 17(2), 243-252. SID. https://sid.ir/paper/646932/en

Vancouver: Copy

DEHGHAN MOHAMMAD MEHDI, BAGHABAN ESLAMINEJAD MOHAMADREZA, MOTALLEBIZADEH NADER, ASHRAFI HALAN JAVAD, TAGIYAR LEILA, SOROORI SARANG, NIKMAHZAR AGBIBI, PEDRAM MIRSEPEHR, SHAHVERDI ABDOLHOSSEIN, KAZEMI MEHRJERDI HOSSEIN, IZADI SADRA. TRANSPLANTATION OF AUTOLOGOUS BONE MARROW MESENCHYMAL STEM CELLS WITH PLATELET-RICH PLASMA ACCELERATE DISTRACTION OSTEOGENESIS IN A CANINE MODEL. CELL JOURNAL (YAKHTEH)[Internet]. 2015;17(2):243-252. Available from: https://sid.ir/paper/646932/en

IEEE: Copy

MOHAMMAD MEHDI DEHGHAN, MOHAMADREZA BAGHABAN ESLAMINEJAD, NADER MOTALLEBIZADEH, JAVAD ASHRAFI HALAN, LEILA TAGIYAR, SARANG SOROORI, AGBIBI NIKMAHZAR, MIRSEPEHR PEDRAM, ABDOLHOSSEIN SHAHVERDI, HOSSEIN KAZEMI MEHRJERDI, and SADRA IZADI, “TRANSPLANTATION OF AUTOLOGOUS BONE MARROW MESENCHYMAL STEM CELLS WITH PLATELET-RICH PLASMA ACCELERATE DISTRACTION OSTEOGENESIS IN A CANINE MODEL,” CELL JOURNAL (YAKHTEH), vol. 17, no. 2, pp. 243–252, 2015, [Online]. Available: https://sid.ir/paper/646932/en

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