PROTECTIVE EFFECTS OF DIALLYL SULFIDE AND CURCUMIN SEPARATELY AGAINST THALLIUM-INDUCED TOXICITY IN RATS (SHORT COMMUNICATION)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ABDEL DAIM MOHAMED M.; ABDOU RANIA H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2015 | Volume:17 | Issue:2 Page(s): 379-388

Download Full-Text

View:

401

Download:

439

Cites:

Information Journal Paper

Title

PROTECTIVE EFFECTS OF DIALLYL SULFIDE AND CURCUMIN SEPARATELY AGAINST THALLIUM-INDUCED TOXICITY IN RATS (SHORT COMMUNICATION)

Author(s)

ABDEL DAIM MOHAMED M. | ABDOU RANIA H. | Issue Writer Certificate

Keywords

GARLIC

TURMERIC

THALLIUM ACETATE

OXIDATIVE STRESS

ANTIOXIDANT

Abstract

Thallium acetate (TI) is a cumulative poison intimately accompanied by an increase in reactive oxygen species (ROS) formation that represents an important risk factor for tissue injury and malfunction. This study aims to determine the possible hepatoprotective and ANTIOXIDANT effects of diallyl sulfide (DAS) from GARLIC and curcumin from TURMERIC against TI-induced liver injury and OXIDATIVE STRESS (OS) in rats.This in vivo animal study divided rats into six groups of 8 rats per group. The first group received saline and served as the control group. The second and third groups received DAS or curcumin only at a dose of 200 mg/kg. The fourth group received TI at a dose of 6.4 mg/kg for 5 consecutive days. The fifth and sixth groups received DAS or curcumin orally 1 hour before TI intoxication at the same dose as the second and third groups. Liver integrity serum enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and g-glutamyltransferase (g-GT) were evaluated. Serum and liver tissue homogenate lipid peroxidation and OS biomarkers were measured. The data were analyzed by one-way ANOVA followed by Duncan’s multiple range test for post hoc analysis using SPSS version 16.TI induced marked oxidative liver damage as shown by significantly (P≤0.05) elevated serum AST, ALT, ALP, LDH and g-GT levels. There were significant (P≤0.05) increases in serum and hepatic malondialdehyde (MDA) and serum nitric oxide (NO) as well as decreased hepatic glutathione (GSH) and catalase (CAT) activities. There were significantly (P≤0.05) less serum and hepatic superoxide dismutase (SOD) and total ANTIOXIDANT capacity (TAC). Pre-treatment with DAS or curcumin ameliorated the changes in most studied biochemical parameters. DAS and curcumin effectively reduced TI-induced liver toxicity.

Cites

No record.

References

Cite

APA: Copy

ABDEL DAIM, MOHAMED M., & ABDOU, RANIA H.. (2015). PROTECTIVE EFFECTS OF DIALLYL SULFIDE AND CURCUMIN SEPARATELY AGAINST THALLIUM-INDUCED TOXICITY IN RATS (SHORT COMMUNICATION). CELL JOURNAL (YAKHTEH), 17(2), 379-388. SID. https://sid.ir/paper/647217/en

Vancouver: Copy

ABDEL DAIM MOHAMED M., ABDOU RANIA H.. PROTECTIVE EFFECTS OF DIALLYL SULFIDE AND CURCUMIN SEPARATELY AGAINST THALLIUM-INDUCED TOXICITY IN RATS (SHORT COMMUNICATION). CELL JOURNAL (YAKHTEH)[Internet]. 2015;17(2):379-388. Available from: https://sid.ir/paper/647217/en

IEEE: Copy

MOHAMED M. ABDEL DAIM, and RANIA H. ABDOU, “PROTECTIVE EFFECTS OF DIALLYL SULFIDE AND CURCUMIN SEPARATELY AGAINST THALLIUM-INDUCED TOXICITY IN RATS (SHORT COMMUNICATION),” CELL JOURNAL (YAKHTEH), vol. 17, no. 2, pp. 379–388, 2015, [Online]. Available: https://sid.ir/paper/647217/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops