DIFFERENTIATION OF ADIPOCYTES AND OSTEOCYTES FROM HUMAN ADIPOSE AND PLACENTAL MESENCHYMAL STEM CELLS

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MOHAMMADI ZAHRA; TAVAKKOL AFSHARI JALIL; KERAMATI MOHAMMAD REZA; HAMIDI ALAMDARI DARYOUSH; GANJI BAKHSH MEYSAM; MORADI ZARMEHRI AZAM; JANGJOO ALI; SADEGHIAN MOHAMMAD HADI; ARAB AMERI MASOUMEH; MOINZADEH LEILA

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2015 | Volume:18 | Issue:3 Page(s): 259-266

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Title

DIFFERENTIATION OF ADIPOCYTES AND OSTEOCYTES FROM HUMAN ADIPOSE AND PLACENTAL MESENCHYMAL STEM CELLS

Author(s)

Keywords

ADULT STEM CELLS

DIFFERENTIATION

FETAL STEM CELLS

MESENCHYMAL STEM CELLS

Abstract

Objective(s): MESENCHYMAL STEM CELLS (MSC) can be isolated from adult tissues such as adipose tissue and other sources. Among these sources, adipose tissue (because of easy access) and placenta (due to its immunomodulatory properties, in addition to other useful properties), have attracted more attention in terms of research. The isolation and comparison of MSC from these two sources provides a proper source for clinical experimentation. The aim of this study was to compare the characteristics of MSC isolated from human adipose tissue and placenta.Materials and Methods: Adipose and placental MSC were isolated from the subcutaneous adipose tissues of 10 healthy women (25 to 40 years) and from a fresh term placenta (n=1), respectively. Stem cells were characterized and compared by flow cytometry using CD29, CD31, CD34, CD44, CD45, CD105, CD166 and HLA-DR markers. Osteocytes and adipocytes were differentiated from isolated human MESENCHYMAL STEM CELLS (HMSC).Results: Adipose and placenta-derived MSC exhibited the same morphological features. ADSC differentiated faster than placenta; however, both were differentiated, taking up to 21 days for osteocyte and 14 days for adipocyte DIFFERENTIATION. About 90% of PLC-MSC and ADSC were positive for CD29, CD44, CD105, and CD166; and negative for CD31, CD34, CD45, and HLA-DR.Conclusion: The two sources of stem cells showed similar surface markers, morphology and DIFFERENTIATION potential and because of their multipotency for differentiating to adipocytes and osteocytes, they can be applied as attractive sources of MSC for regenerative medicine.

Cites

LOVASTATIN REDUCES STEMNESS VIA EPIGENETIC REPROGRAMING OF BMP2 AND GATA2 IN HUMAN ENDOMETRIUM AND ENDOMETRIOSIS

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APA: Copy

MOHAMMADI, ZAHRA, TAVAKKOL AFSHARI, JALIL, KERAMATI, MOHAMMAD REZA, HAMIDI ALAMDARI, DARYOUSH, GANJI BAKHSH, MEYSAM, MORADI ZARMEHRI, AZAM, JANGJOO, ALI, SADEGHIAN, MOHAMMAD HADI, ARAB AMERI, MASOUMEH, & MOINZADEH, LEILA. (2015). DIFFERENTIATION OF ADIPOCYTES AND OSTEOCYTES FROM HUMAN ADIPOSE AND PLACENTAL MESENCHYMAL STEM CELLS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(3), 259-266. SID. https://sid.ir/paper/647760/en

Vancouver: Copy

MOHAMMADI ZAHRA, TAVAKKOL AFSHARI JALIL, KERAMATI MOHAMMAD REZA, HAMIDI ALAMDARI DARYOUSH, GANJI BAKHSH MEYSAM, MORADI ZARMEHRI AZAM, JANGJOO ALI, SADEGHIAN MOHAMMAD HADI, ARAB AMERI MASOUMEH, MOINZADEH LEILA. DIFFERENTIATION OF ADIPOCYTES AND OSTEOCYTES FROM HUMAN ADIPOSE AND PLACENTAL MESENCHYMAL STEM CELLS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(3):259-266. Available from: https://sid.ir/paper/647760/en

IEEE: Copy

ZAHRA MOHAMMADI, JALIL TAVAKKOL AFSHARI, MOHAMMAD REZA KERAMATI, DARYOUSH HAMIDI ALAMDARI, MEYSAM GANJI BAKHSH, AZAM MORADI ZARMEHRI, ALI JANGJOO, MOHAMMAD HADI SADEGHIAN, MASOUMEH ARAB AMERI, and LEILA MOINZADEH, “DIFFERENTIATION OF ADIPOCYTES AND OSTEOCYTES FROM HUMAN ADIPOSE AND PLACENTAL MESENCHYMAL STEM CELLS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 3, pp. 259–266, 2015, [Online]. Available: https://sid.ir/paper/647760/en

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