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Information Journal Paper

Title

A RARE DE NOVO COMPLEX CHROMOSOMAL REARRANGEMENT (CCR) INVOLVING FOUR CHROMOSOMES IN AN OLIGO-ASTHENOSPERM INFERTILE MAN (CASE REPORT)

Pages

  377-382

Keywords

COMPLEX CHROMOSOMAL REARRANGEMENT (CCR) 

Abstract

 Complex chromosomal rearrangements (CCRs) are rare events involving more than two chromosomes and over two breakpoints. They are usually associated with INFERTILITY or sub fertility in male carriers. Here we report a novel case of a CCR in a 30-year-old oligoasthenosperm man with a history of varicocelectomy, normal testes size and normal endocrinology profile referred for chromosome analysis to the Genetics unit of Royan Reproductive Biomedicine Research Center. Chromosomal analysis was performed using peripheral blood lymphocyte cultures and analyzed by GTG banding. Additional tests such as C-banding and multicolor fluorescence in situ hybridization (FISH) procedure for each of the involved chromosomes were performed to determine the patterns of the segregations. Y chromosome microdeletions in the azoospermia factor (AZF) region were analyzed with multiplex polymerase chain reaction. To identify the history and origin of this CCR, all the family members were analyzed. No micro deletion in Y chromosome was detected. The samede novo reciprocal exchange was also found in his monozygous twin brother. The other siblings and parents were normal. CCRs are associated with male INFERTILITY as a result of spermatogenic disruption due to complex meiotic configurations and the production of chromosomally abnormal sperms. These chromosomal rearrangements might have an influence on decreasing the number of sperms.

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    Cite

    APA: Copy

    ASIA, SABA, VAZIRI NASAB, HAMED, SABBAGHIAN, MARJAN, KALANTARI, HAMID, ZARI MORADI, SHABNAM, GOURABI, HAMID, & MOHSENI MEYBODI, ANAHITA. (2014). A RARE DE NOVO COMPLEX CHROMOSOMAL REARRANGEMENT (CCR) INVOLVING FOUR CHROMOSOMES IN AN OLIGO-ASTHENOSPERM INFERTILE MAN (CASE REPORT). CELL JOURNAL (YAKHTEH), 16(3 (63)), 377-382. SID. https://sid.ir/paper/648030/en

    Vancouver: Copy

    ASIA SABA, VAZIRI NASAB HAMED, SABBAGHIAN MARJAN, KALANTARI HAMID, ZARI MORADI SHABNAM, GOURABI HAMID, MOHSENI MEYBODI ANAHITA. A RARE DE NOVO COMPLEX CHROMOSOMAL REARRANGEMENT (CCR) INVOLVING FOUR CHROMOSOMES IN AN OLIGO-ASTHENOSPERM INFERTILE MAN (CASE REPORT). CELL JOURNAL (YAKHTEH)[Internet]. 2014;16(3 (63)):377-382. Available from: https://sid.ir/paper/648030/en

    IEEE: Copy

    SABA ASIA, HAMED VAZIRI NASAB, MARJAN SABBAGHIAN, HAMID KALANTARI, SHABNAM ZARI MORADI, HAMID GOURABI, and ANAHITA MOHSENI MEYBODI, “A RARE DE NOVO COMPLEX CHROMOSOMAL REARRANGEMENT (CCR) INVOLVING FOUR CHROMOSOMES IN AN OLIGO-ASTHENOSPERM INFERTILE MAN (CASE REPORT),” CELL JOURNAL (YAKHTEH), vol. 16, no. 3 (63), pp. 377–382, 2014, [Online]. Available: https://sid.ir/paper/648030/en

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