THE CORRELATION BETWEEN BLOOD BIOMARKERS AND BLOOD LEAD LEVELS IN PREECLAMPSIA

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BAYAT FATEMEH; AMIR ALIAKBARI SEDIGHEH; DABIRI ATOUSA; NASIRI MALIHE; MELLATI ALI OSAT

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Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2016 | Volume:19 | Issue:34 Page(s): 10-17

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Title

THE CORRELATION BETWEEN BLOOD BIOMARKERS AND BLOOD LEAD LEVELS IN PREECLAMPSIA

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Keywords

BLOOD LEADQ2

COMPLETE BLOOD COUNTQ1

PREECLAMPSIAQ1

Abstract

Introduction: Considering the importance of PREECLAMPSIA and its effect on hematologic indices, and also the studies showing the effect of lead as a toxic metal on these indices, the present study was performed with aim to investigate the correlation of serum lead with hematologic indices in women with PREECLAMPSIA with no occupational exposure to lead.Methods: This correlation study was performed on 80 pregnant women with PREECLAMPSIA hospitalized in Zanjan Ayatolah Mousavi hospital in 2015. At entry to the study, 3.5 ml of venous blood samples were taken from participants to assess serum lead level and hematologic indices. Demographic and obstetric characteristics of participates were also recorded. Serum lead level was measured using potentiometric method with Ion3 device, and hematologic indices were analyzed with Symex device. Data were analyzed by SPSS software (version 22) and Chi-square and Pearson correlation test. P<0.05 was considered significant.Results: Mean serum lead level among 80 participants was 8.04±3.4 mg/dl. BLOOD LEAD level showed a positive correlation with Platelet Distribution Weight (PDW: r=-0.300, P=0.17), and a negative and significant one with Platelet Large Cell Range (PLCR: r=-0.260, P=0.047). BLOOD LEAD level also showed positive significant relationship with BUN (BUN: r=0.377, P=0.001) and blood creatinine (Cr: r=0.288, P=0.012), but showed no relationship with other blood indices.Conclusion: BLOOD LEAD affects on blood biomarkers, so it is recommended that strategies be planned and implemented for reducing exposure to environmental lead especially in pregnant women.

Cites

Frequency of Protein C, S and Antithrombin III Deficiency and Presence of Antibodies of Antiphospholipid Syndrome in Women with Recurrent Abortion

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APA: Copy

BAYAT, FATEMEH, AMIR ALIAKBARI, SEDIGHEH, DABIRI, ATOUSA, NASIRI, MALIHE, & MELLATI, ALI OSAT. (2016). THE CORRELATION BETWEEN BLOOD BIOMARKERS AND BLOOD LEAD LEVELS IN PREECLAMPSIA. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 19(34), 10-17. SID. https://sid.ir/paper/64809/en

Vancouver: Copy

BAYAT FATEMEH, AMIR ALIAKBARI SEDIGHEH, DABIRI ATOUSA, NASIRI MALIHE, MELLATI ALI OSAT. THE CORRELATION BETWEEN BLOOD BIOMARKERS AND BLOOD LEAD LEVELS IN PREECLAMPSIA. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2016;19(34):10-17. Available from: https://sid.ir/paper/64809/en

IEEE: Copy

FATEMEH BAYAT, SEDIGHEH AMIR ALIAKBARI, ATOUSA DABIRI, MALIHE NASIRI, and ALI OSAT MELLATI, “THE CORRELATION BETWEEN BLOOD BIOMARKERS AND BLOOD LEAD LEVELS IN PREECLAMPSIA,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 19, no. 34, pp. 10–17, 2016, [Online]. Available: https://sid.ir/paper/64809/en

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