AMYLOID-BASED THERAPIES DID FAIL AGAIN! IT IS THE RIGHT TIME TO CHANGE OUR VISION ON BUILDING BLOCK OF ALZHEIMER'S DISEASE (LETTER TO EDITOR)

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MAHMOUDI MORTEZA

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Journal Paper

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Journal: Current Journal of Neurology Year:2014 | Volume:13 | Issue:1 Page(s): 48-49

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Title

AMYLOID-BASED THERAPIES DID FAIL AGAIN! IT IS THE RIGHT TIME TO CHANGE OUR VISION ON BUILDING BLOCK OF ALZHEIMER'S DISEASE (LETTER TO EDITOR)

Author(s)

MAHMOUDI MORTEZA | Issue Writer Certificate

Keywords

AMYLOID

ALZHEIMER'S DISEASE

THERAPY

DEMENTIA

Abstract

Alois Alzheimer, the Bavarian neuropathologist, first introduced the ALZHEIMER'S DISEASE (AD) in 1906 following detection of AMYLOID plaques, neurofibrillary tangles, and arteriosclerotic changes in the brain of his patient. AD is known as the most frequent global form of DEMENTIA, these days, representing 50-80% of all cases1 with huge patient maintenance costs (i.e.172 billion US dollars in 2010 at the United States1 predicting to reach 1 trillion dollars by 2050).2 The most well recognized hallmarks of AD neuropathology known now are the extracellular AMYLOID plaque burden, intracellular neurofibrillary tangles, and microtubule destabilizations.3 Misfolding each of these proteinaceous entities have their specific mechanisms to contribute to neuronal cell death and have been the subject of plethora of researches in the last decade.3

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APA: Copy

MAHMOUDI, MORTEZA. (2014). AMYLOID-BASED THERAPIES DID FAIL AGAIN! IT IS THE RIGHT TIME TO CHANGE OUR VISION ON BUILDING BLOCK OF ALZHEIMER'S DISEASE (LETTER TO EDITOR). CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 13(1), 48-49. SID. https://sid.ir/paper/648130/en

Vancouver: Copy

MAHMOUDI MORTEZA. AMYLOID-BASED THERAPIES DID FAIL AGAIN! IT IS THE RIGHT TIME TO CHANGE OUR VISION ON BUILDING BLOCK OF ALZHEIMER'S DISEASE (LETTER TO EDITOR). CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2014;13(1):48-49. Available from: https://sid.ir/paper/648130/en

IEEE: Copy

MORTEZA MAHMOUDI, “AMYLOID-BASED THERAPIES DID FAIL AGAIN! IT IS THE RIGHT TIME TO CHANGE OUR VISION ON BUILDING BLOCK OF ALZHEIMER'S DISEASE (LETTER TO EDITOR),” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 13, no. 1, pp. 48–49, 2014, [Online]. Available: https://sid.ir/paper/648130/en

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