مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EXPRESSION OF MELANOCORTIN-4 RECEPTOR AND AGOUTI-RELATED PEPTIDE MRNAS IN ARCUATE NUCLEUS DURING LONG TERM MALNUTRITION OF FEMALE OVARIECTOMIZED RATS

Pages

  104-107

Abstract

 Objective: MELANOCORTIN-4 RECEPTOR (MC4R) and AGOUTI-RELATED PEPTIDE (AgRP) are involved in energy homeostasis in the RAT. The aim of the present study was to evaluate the expression of MC4R and AgRP mRNAs in arcuate nucleus (ARC) during long term MALNUTRITION of female ovariectomized RATs.Materials and Methods: Ten female ovariectomized RATs were divided into two equal groups (n=6) of normal and restricted diet groups. Using real-time PCR, the relative expressions (compared to controls) of MC4R and AgRP mRNAs were compared between both diet groups.Results: The relative expression of MC4R and AgRP mRNA in the ARC of female ovariectomized RATs during long term MALNUTRITION was higher than those with normal diet (P<0.05).Conclusion: Changes in the relative expression level of MC4R and AgRP mRNAs during long term MALNUTRITION of RAT indicated a stimulatory role of MC4R and AgRP in regulating energy balance in ARC of RAT HYPOTHALAMUS.

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    Cite

    APA: Copy

    SABET SARVESTANI, FATEMEH, TAMADON, AMIN, HEMATZADEH, AIDA, JAHANARA, MALIHEH, JAFARZADEH SHIRAZI, MOHAMMAD REZA, MOGHADAM, ALI, NIAZI, ALI, & MOGHIMINASR, REZA. (2015). EXPRESSION OF MELANOCORTIN-4 RECEPTOR AND AGOUTI-RELATED PEPTIDE MRNAS IN ARCUATE NUCLEUS DURING LONG TERM MALNUTRITION OF FEMALE OVARIECTOMIZED RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(1), 104-107. SID. https://sid.ir/paper/649783/en

    Vancouver: Copy

    SABET SARVESTANI FATEMEH, TAMADON AMIN, HEMATZADEH AIDA, JAHANARA MALIHEH, JAFARZADEH SHIRAZI MOHAMMAD REZA, MOGHADAM ALI, NIAZI ALI, MOGHIMINASR REZA. EXPRESSION OF MELANOCORTIN-4 RECEPTOR AND AGOUTI-RELATED PEPTIDE MRNAS IN ARCUATE NUCLEUS DURING LONG TERM MALNUTRITION OF FEMALE OVARIECTOMIZED RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(1):104-107. Available from: https://sid.ir/paper/649783/en

    IEEE: Copy

    FATEMEH SABET SARVESTANI, AMIN TAMADON, AIDA HEMATZADEH, MALIHEH JAHANARA, MOHAMMAD REZA JAFARZADEH SHIRAZI, ALI MOGHADAM, ALI NIAZI, and REZA MOGHIMINASR, “EXPRESSION OF MELANOCORTIN-4 RECEPTOR AND AGOUTI-RELATED PEPTIDE MRNAS IN ARCUATE NUCLEUS DURING LONG TERM MALNUTRITION OF FEMALE OVARIECTOMIZED RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 1, pp. 104–107, 2015, [Online]. Available: https://sid.ir/paper/649783/en

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