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Information Journal Paper

Title

EFFECT OF CYPERUS ROTUNDUS ON ISCHEMIA-INDUCED BRAIN DAMAGE AND MEMORY DYSFUNCTION IN RATS

Pages

  199-204

Abstract

 Objective(s): Global CEREBRAL ISCHEMIA-reperfusion injury causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the possible neuroprotective effects of the ethanol extract of CYPERUS ROTUNDUS (EECR) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and SPATIAL MEMORY.Materials and Methods: Treatment group (EECR, 100 mg/kg/day) was gavaged from 4 days before, to 3 days after ischemia. MORRIS WATER MAZE test was performed 1 week after ischemia for 4 days. Brain tissue was prepared for Nissl staining.Results: Our data showed no statistical difference between the treatment and ischemia groups in water maze task. So, treatment of ischemia with EECR cannot improve spatial learning and memory. On the contrary EECR ameliorated the CA1 pyramidal cell loss due to transient global ischemia/ reperfusion injury.Conclusion: These results suggest that EECR cannot reduce the ischemia-induced, cognitive impairments seen after transient, global CEREBRAL ISCHEMIA but can prevent pyramidal cell loss in CA1 region of hippocampus.

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    APA: Copy

    HASHEM DABAGHIAN, FATANEH, HASHEMI, MEHRDAD, ENTEZARI, MALIHEH, MOVASSAGHI, SHABNAM, GOUSHEGIR, S.ASHRAFODIN, MOVAFAGH, ABOLFAZL, & NADIA SHARIFI, ZAHRA. (2015). EFFECT OF CYPERUS ROTUNDUS ON ISCHEMIA-INDUCED BRAIN DAMAGE AND MEMORY DYSFUNCTION IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(2), 199-204. SID. https://sid.ir/paper/650893/en

    Vancouver: Copy

    HASHEM DABAGHIAN FATANEH, HASHEMI MEHRDAD, ENTEZARI MALIHEH, MOVASSAGHI SHABNAM, GOUSHEGIR S.ASHRAFODIN, MOVAFAGH ABOLFAZL, NADIA SHARIFI ZAHRA. EFFECT OF CYPERUS ROTUNDUS ON ISCHEMIA-INDUCED BRAIN DAMAGE AND MEMORY DYSFUNCTION IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(2):199-204. Available from: https://sid.ir/paper/650893/en

    IEEE: Copy

    FATANEH HASHEM DABAGHIAN, MEHRDAD HASHEMI, MALIHEH ENTEZARI, SHABNAM MOVASSAGHI, S.ASHRAFODIN GOUSHEGIR, ABOLFAZL MOVAFAGH, and ZAHRA NADIA SHARIFI, “EFFECT OF CYPERUS ROTUNDUS ON ISCHEMIA-INDUCED BRAIN DAMAGE AND MEMORY DYSFUNCTION IN RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 2, pp. 199–204, 2015, [Online]. Available: https://sid.ir/paper/650893/en

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