ROLE OF C-FIBERS IN PAIN AND MORPHINE INDUCED ANALGESIA/HYPERALGESIA IN RATS

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ALIZADEH ZAHRA; FEREIDONI MASOUD; BEHNAM RASSOULI MORTEZA; HOSSEINI SHIRIN

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Journal Paper

Paper Information

Journal: Current Journal of Neurology Year:2014 | Volume:13 | Issue:1 Page(s): 19-27

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Title

ROLE OF C-FIBERS IN PAIN AND MORPHINE INDUCED ANALGESIA/HYPERALGESIA IN RATS

Author(s)

ALIZADEH ZAHRA | FEREIDONI MASOUD | BEHNAM RASSOULI MORTEZA | HOSSEINI SHIRIN | Issue Writer Certificate

Keywords

C-FIBERS

PAIN

ANALGESIA

HYPERALGESIA

MORPHINE

Abstract

Background: Usual dosage of MORPHINE (10 mg/kg) induces ANALGESIA and ultra-low dose (ULD) of MORPHINE (1 mg/kg); HYPERALGESIA, and C-FIBERS are also bearing μ- opioid receptors; here the importance of C-FIBERS on PAIN and MORPHINE induced ANALGESIA/hyperalgesia is questioned and investigated using PAIN evaluation methods and infant capsaicin treating for C-FIBERS lesioning.Methods: Wistar male rats (200-250 grams) were assigned to three categories i.e. control, sham (receiving neonatal capsaicin vehicle) and c-lesion (receiving neonatal capsaicin), each one with three groups (n=7). They were injected intraperitoneally with single dosage of saline, 10 mg/kg or 1 mg/kg MORPHINE, respectively. Thermal PAIN threshold was evaluated using the tail flick test before and 30 minutes after the injections. Chemical PAIN was assessed using the formalin test (FT) 30 minutes after the administrations.Results: Results indicated that thermal (P<0.001) and chemical PAINs in both neurogenic and inflammatory phases of FT (P<0.05) were reduced in C-lesion animals. In the C-normal and C-lesion animals, 10 mg/kg MORPHINE exerted ANALGESIA both in thermal (P<0.001) and two phases of FT (P<0.01), but it was more potent in C-lesion animals (P<0.05). Although ULD of MORPHINE in C-normal animals produced hyperalgesic effect in thermal and chemical PAINs (P<0.001), in C-lesion animals, it produced ANALGESIA (P<0.05) at the neurogenic phase of FT.Conclusion: Results can raise the C-FIBERS involvement for a significant portion of nociceptive transmission, because C-lesioning potentiated MORPHINE induced ANALGESIA and eliminated ULD of MORPHINE induced HYPERALGESIA. Therefore C and Ad fibers can be involved in MORPHINE ANALGESIA; while, just C-FIBERS are possibly responsible for only presynaptically hyperalgesic/excitatory action of ULD in MORPHINE.

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APA: Copy

ALIZADEH, ZAHRA, FEREIDONI, MASOUD, BEHNAM RASSOULI, MORTEZA, & HOSSEINI, SHIRIN. (2014). ROLE OF C-FIBERS IN PAIN AND MORPHINE INDUCED ANALGESIA/HYPERALGESIA IN RATS. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 13(1), 19-27. SID. https://sid.ir/paper/651551/en

Vancouver: Copy

ALIZADEH ZAHRA, FEREIDONI MASOUD, BEHNAM RASSOULI MORTEZA, HOSSEINI SHIRIN. ROLE OF C-FIBERS IN PAIN AND MORPHINE INDUCED ANALGESIA/HYPERALGESIA IN RATS. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2014;13(1):19-27. Available from: https://sid.ir/paper/651551/en

IEEE: Copy

ZAHRA ALIZADEH, MASOUD FEREIDONI, MORTEZA BEHNAM RASSOULI, and SHIRIN HOSSEINI, “ROLE OF C-FIBERS IN PAIN AND MORPHINE INDUCED ANALGESIA/HYPERALGESIA IN RATS,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 13, no. 1, pp. 19–27, 2014, [Online]. Available: https://sid.ir/paper/651551/en

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