Nucleic acid vaccines for human papillomavirus; prevention or treatment

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Moniri Javadhesari Solmaz; Pourseif Sepehr; Khakpour Keyvan

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Journal Paper

Paper Information

Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2019 | Volume:22 | Issue:7 Page(s): 77-88

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Title

Nucleic acid vaccines for human papillomavirus; prevention or treatment

Author(s)

Moniri Javadhesari Solmaz | Pourseif Sepehr | Khakpour Keyvan | Issue Writer Certificate

Keywords

Cervical cancerQ2

DNA VaccinesQ1

Human papillomavirusQ1

RNA VaccinesQ1

Therapeutic vaccinesQ1

Abstract

Introduction: Cervical cancer is the fourth common cancer among women. In almost all cases of this cancer, infection to a high risk human papilloma virus (HPV) especially type 16 and 18 is observed. HPV is also the cause of other cancers such as oropharyngeal, anorectal and skin. This study was performed with aim to evaluate the vaccines available or under investigation to prevent or treat HPV infection. Methods: In this review study, the keywords of HPV, cervix cancer, DNA vaccine, RNA vaccine, and prevention or treatment of HPV infections were searched in databases of PubMed, Science direct, Scopus and Google Scholar from 2000 to 2018. The recent articles published in English Q1 journals were selected, and the articles with incomplete or irrelevant data were excluded from the study. Results: Despite the available vaccines to prevent HPV infection, ongoing research is continued to develop assorted vaccines against it, because available vaccines don’ t prevent all high risk types of HPV; also they are not effective on those who are already infected and have HPV associated malignancies or cancer. Nucleic acid based (DNA or RNA) vaccines are of promising approaches. Conclusion: Nucleic acid vaccines have promising outcomes due to safety, stability, simplicity of providing and ability to induce antigen-specific immunity. Currently, GX-188E, VGX-3100, ZNF– 603 and ZNF-758 vaccines are successfully passing clinical trials based on E6 and E7 genes of HPV. These vaccines caused hopes for a vaccine to treat those who are already infected or have cancer.

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APA: Copy

Moniri Javadhesari, Solmaz, Pourseif, Sepehr, & Khakpour, Keyvan. (2019). Nucleic acid vaccines for human papillomavirus; prevention or treatment. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 22(7 ), 77-88. SID. https://sid.ir/paper/65255/en

Vancouver: Copy

Moniri Javadhesari Solmaz, Pourseif Sepehr, Khakpour Keyvan. Nucleic acid vaccines for human papillomavirus; prevention or treatment. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2019;22(7 ):77-88. Available from: https://sid.ir/paper/65255/en

IEEE: Copy

Solmaz Moniri Javadhesari, Sepehr Pourseif, and Keyvan Khakpour, “Nucleic acid vaccines for human papillomavirus; prevention or treatment,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 22, no. 7 , pp. 77–88, 2019, [Online]. Available: https://sid.ir/paper/65255/en

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