EXPRESSION OF T-CELL IMMUNOGLOBULIN- AND MUCIN-DOMAIN-CONTAINING MOLECULE-3 ON LYMPHOCYTES FROM HENOCH-SCHOENLEIN PURPURA PATIENTS

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YUAN LI PING; BO YAN; LING LU; BO HU

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pediatrics Year:2013 | Volume:23 | Issue:3 Page(s): 345-348

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Information Journal Paper

Title

EXPRESSION OF T-CELL IMMUNOGLOBULIN- AND MUCIN-DOMAIN-CONTAINING MOLECULE-3 ON LYMPHOCYTES FROM HENOCH-SCHOENLEIN PURPURA PATIENTS

Author(s)

YUAN LI PING | BO YAN | LING LU | BO HU | Issue Writer Certificate

Keywords

HENOCH-SCHOENLEIN PURPURA

T-CELL IMMUNOGLOBULIN

MUCIN DOMAIN CONTAINING 3 PROTEIN

TIM-3 PROTEIN

IMMUNOGLOBULIN A

Abstract

Objective: To investigate T-CELL IMMUNOGLOBULIN domain and mucin domain-containing molecule-3 (Tim-3) and its ligand galectin-9 mRNA expression in peripheral blood mononuclear cells (PBMCs) from HENOCH-SCHOENLEIN PURPURA (HSP) patients.Methods: Quantitative real-time reverse transcription-polymerase chain reaction (PCR) was used to examine the mRNA expression of Tim-3 and its ligand galectin-9 in PBMCs from HSP patients. ELISA methods were used to examine the levels of serum IFN-g and IMMUNOGLOBULIN A1 (IgA1). The Spearman rank test was used for correlation analysis between Tim-3, galectin-9 mRNA expression and serum IFN-g and IgA1 levels, respectively.Findings: The results showed that Tim-3 and galectin-9 mRNA expression was obviously higher in patients, which was closely correlated with serum IFN-g and IgA1, respectively.Conclusion: The results suggested that Tim-3/Tim-3L may be related to the pathogenesis of HSP.

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APA: Copy

YUAN, LI PING, BO, YAN, LING, LU, & BO, HU. (2013). EXPRESSION OF T-CELL IMMUNOGLOBULIN- AND MUCIN-DOMAIN-CONTAINING MOLECULE-3 ON LYMPHOCYTES FROM HENOCH-SCHOENLEIN PURPURA PATIENTS. IRANIAN JOURNAL OF PEDIATRICS, 23(3), 345-348. SID. https://sid.ir/paper/652590/en

Vancouver: Copy

YUAN LI PING, BO YAN, LING LU, BO HU. EXPRESSION OF T-CELL IMMUNOGLOBULIN- AND MUCIN-DOMAIN-CONTAINING MOLECULE-3 ON LYMPHOCYTES FROM HENOCH-SCHOENLEIN PURPURA PATIENTS. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2013;23(3):345-348. Available from: https://sid.ir/paper/652590/en

IEEE: Copy

LI PING YUAN, YAN BO, LU LING, and HU BO, “EXPRESSION OF T-CELL IMMUNOGLOBULIN- AND MUCIN-DOMAIN-CONTAINING MOLECULE-3 ON LYMPHOCYTES FROM HENOCH-SCHOENLEIN PURPURA PATIENTS,” IRANIAN JOURNAL OF PEDIATRICS, vol. 23, no. 3, pp. 345–348, 2013, [Online]. Available: https://sid.ir/paper/652590/en

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