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Information Journal Paper

Title

PROGESTERONE/ESTRADIOL RATIO AS A PREDICTOR IN THE ART CYCLES WITH PREMATURE PROGESTERONE ELEVATION ON THE DAY OF HCG TRIGGER

Pages

  155-161

Abstract

 Background: The purpose of the study was to evaluate the role of Progesterone/ Estradiol (P4/E2) ratio as a predictive tool for clinical PREGNANCY in ART cycles with a premature progesterone rise of>1.5 ng/ml on the day of human chorionic gonadotropin (hCG) trigger.Methods: Retrospective analysis was done on 569 fresh embryo transfer cycles from January 2011 to December 2012 at the infertility unit of a tertiary care hospital. Age, BMI, number of cycles and number of clinical pregnancies have been considered.Results: The overall clinical PREGNANCY rate per embryo transfer was 42.8% (244/ 569). The clinical PREGNANCY rate in the 36 cycles with progesterone (P4) level>1.5 ng/ml was significantly lower than the 533 cycles with normal p4≤1.5 ng/ml (22.2% vs.44.2%; p=0.0092). The 36 cycles with progesterone level>1.5 ng/ml were divided into subgroups of P4/E2>1 (n=20) and P4/E2≤1 (n=16). The 20 cycles with P4/E2 >1 and P4>1.5 ng/ml had a significantly lower PREGNANCY rate than the cycles with P4≤1.5 ng/ml (15% vs.42.8%; p=0.0103). The 15 cycles with P4/E2≤1 and P4>1.5 ng/ml had a similar PREGNANCY rate as the cycles with P4≤1.5 ng/ml.Conclusion: A PREMATURE PROGESTERONE ELEVATION in ART cycles is possibly associated with lower clinical PREGNANCY rates; this adverse impact of elevated progesterone seems to be limited mainly to a subgroup with an elevated P4/E2 ratio>1.

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    APA: Copy

    MASCARENHAS, MARIANO, SHASHIKANT KAMATH, MOHAN, CHANDY, ACHAMMA, & KUNJUMMEN, ALEYAMMA T.. (2015). PROGESTERONE/ESTRADIOL RATIO AS A PREDICTOR IN THE ART CYCLES WITH PREMATURE PROGESTERONE ELEVATION ON THE DAY OF HCG TRIGGER. JOURNAL OF REPRODUCTION AND INFERTILITY, 16(3), 155-161. SID. https://sid.ir/paper/656350/en

    Vancouver: Copy

    MASCARENHAS MARIANO, SHASHIKANT KAMATH MOHAN, CHANDY ACHAMMA, KUNJUMMEN ALEYAMMA T.. PROGESTERONE/ESTRADIOL RATIO AS A PREDICTOR IN THE ART CYCLES WITH PREMATURE PROGESTERONE ELEVATION ON THE DAY OF HCG TRIGGER. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2015;16(3):155-161. Available from: https://sid.ir/paper/656350/en

    IEEE: Copy

    MARIANO MASCARENHAS, MOHAN SHASHIKANT KAMATH, ACHAMMA CHANDY, and ALEYAMMA T. KUNJUMMEN, “PROGESTERONE/ESTRADIOL RATIO AS A PREDICTOR IN THE ART CYCLES WITH PREMATURE PROGESTERONE ELEVATION ON THE DAY OF HCG TRIGGER,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 16, no. 3, pp. 155–161, 2015, [Online]. Available: https://sid.ir/paper/656350/en

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