مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EFFECT OF NANOSILVER PARTICLES ON PROCASPASE-3 EXPRESSION IN NEWBORN RAT BRAIN

Pages

  489-493

Abstract

 Objective: Nanotechnology focuses on materials having at least one dimension of less than 100 nanometers. Nanomaterials such as Nanosilver (NS) have unique physical and chemical properties such as size, shape, surface charge. NS particles are thought to induce neuronal degeneration and necrosis in the BRAIN. It has been reported that NS particles generate free radicals and oxidative stress which alters gene expression and induces APOPTOSIS. This study was designed to evaluate whether the detrimental effect of NS particles is through the activation ofProcaspase-3 during fetal neural development.Materials and Methods: In this experimental study, thirty Wistar female rats at day one of pregnancy were semi-randomly distributed into three groups of ten. Group 1, the control group, had no treatment. From day 1 to the end of pregnancy, groups 2 and 3 received 1 and 10 ppm NS respectively via drinking water. Newborn rats were sacrificed immediately after birth and their BRAINs were dissected and kept frozen. Total RNA, extracted from BRAIN homogenates, was reverse transcribed to cDNA. Quantitative real-time polymerase chain reaction (PCR) analysis was undertaken to estimate the expression level ofProcaspase-3.Results: Developmental exposure to NS induced neurotoxicity and APOPTOSIS. This correlated with a significant increase inProcaspase-3 expression level especially at 10 ppm NS.Conclusion: The pro-apoptotic activity of NS in cells is likely to due to the dysregulation ofProcaspase-3.

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    Cite

    APA: Copy

    GANJURI, MOSTAFA, MOSHTAGHIAN, JAMAL, & GHAEDI, KAMRAN. (2015). EFFECT OF NANOSILVER PARTICLES ON PROCASPASE-3 EXPRESSION IN NEWBORN RAT BRAIN. CELL JOURNAL (YAKHTEH), 17(3 (67)), 489-493. SID. https://sid.ir/paper/658568/en

    Vancouver: Copy

    GANJURI MOSTAFA, MOSHTAGHIAN JAMAL, GHAEDI KAMRAN. EFFECT OF NANOSILVER PARTICLES ON PROCASPASE-3 EXPRESSION IN NEWBORN RAT BRAIN. CELL JOURNAL (YAKHTEH)[Internet]. 2015;17(3 (67)):489-493. Available from: https://sid.ir/paper/658568/en

    IEEE: Copy

    MOSTAFA GANJURI, JAMAL MOSHTAGHIAN, and KAMRAN GHAEDI, “EFFECT OF NANOSILVER PARTICLES ON PROCASPASE-3 EXPRESSION IN NEWBORN RAT BRAIN,” CELL JOURNAL (YAKHTEH), vol. 17, no. 3 (67), pp. 489–493, 2015, [Online]. Available: https://sid.ir/paper/658568/en

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