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Information Journal Paper

Title

THE RELATIONSHIP BETWEEN SEMINAL MELATONIN WITH SPERM PARAMETERS, DNA FRAGMENTATION AND NUCLEAR MATURITY IN INTRA-CYTOPLASMIC SPERM INJECTION CANDIDATES

Pages

  547-553

Abstract

 Objective: MELATONIN, the chief secretory product of the pineal gland, regulates dynamic physiological adaptations that occur in seasonally breeding mammals as a response to changes in daylight hours. Because of the presence of MELATONIN in semen and the membrane MELATONIN receptor in spermatozoa, the impact of MELATONIN on the regulation of male infertility is still questionable. The aim of this study was to determine the effects of endogenous MELATONIN on human semen parameters (sperm concentration, motility and normal morphology), DNA FRAGMENTATION (DF) and nuclear maturity.Materials and Methods: In this clinical prospective study, semen samples from 75 infertile men were routinely analyzed and assessed for MELATONIN and total ANTIOXIDANT capacity (TAC) levels using the enzyme-linked immunosorbent assay (ELISA) and colorimetric assay kits, respectively. DF was examined by the sperm chromatin dispersion (SCD) test.Acidic aniline blue staining was used to detect chromatin defects in the sperm nuclei.Results: There was no significant correlation between seminal plasma MELATONIN and TAC with sperm parameters and nuclear maturity. However, we observed a positive significant correlation between DF and MELATONIN level (r=0.273, P<0.05).Conclusion: MELATONIN in seminal plasma is positively correlated with damaged sperm DNA of infertile patients. The mechanism of this phenomenon needs further study.

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    APA: Copy

    SHARBATOGHLI, MINA, REZAZADEH VALOJERDI, MOJTABA, BAHADORI, MOHAMAD HADI, SALMAN YAZDI, REZA, & RASHKI GHALENO, LEILA. (2015). THE RELATIONSHIP BETWEEN SEMINAL MELATONIN WITH SPERM PARAMETERS, DNA FRAGMENTATION AND NUCLEAR MATURITY IN INTRA-CYTOPLASMIC SPERM INJECTION CANDIDATES. CELL JOURNAL (YAKHTEH), 17(3 (67)), 547-553. SID. https://sid.ir/paper/658955/en

    Vancouver: Copy

    SHARBATOGHLI MINA, REZAZADEH VALOJERDI MOJTABA, BAHADORI MOHAMAD HADI, SALMAN YAZDI REZA, RASHKI GHALENO LEILA. THE RELATIONSHIP BETWEEN SEMINAL MELATONIN WITH SPERM PARAMETERS, DNA FRAGMENTATION AND NUCLEAR MATURITY IN INTRA-CYTOPLASMIC SPERM INJECTION CANDIDATES. CELL JOURNAL (YAKHTEH)[Internet]. 2015;17(3 (67)):547-553. Available from: https://sid.ir/paper/658955/en

    IEEE: Copy

    MINA SHARBATOGHLI, MOJTABA REZAZADEH VALOJERDI, MOHAMAD HADI BAHADORI, REZA SALMAN YAZDI, and LEILA RASHKI GHALENO, “THE RELATIONSHIP BETWEEN SEMINAL MELATONIN WITH SPERM PARAMETERS, DNA FRAGMENTATION AND NUCLEAR MATURITY IN INTRA-CYTOPLASMIC SPERM INJECTION CANDIDATES,” CELL JOURNAL (YAKHTEH), vol. 17, no. 3 (67), pp. 547–553, 2015, [Online]. Available: https://sid.ir/paper/658955/en

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