CELL ATTACHMENT AND PROLIFERATION OF HUMAN ADIPOSE-DERIVED STEM CELLS ON PLGA/CHITOSAN ELECTROSPUN NANO-BIOCOMPOSITE

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RAZAVI SHAHNAZ; KARBASI SAEED; MORSHED MOHAMMAD; ZARKESH ESFAHANI HAMID; GOLOZAR MOHAMMAD; VAEZIFAR SEDIGHEH

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Journal: Cell Journal (Yakhteh) Year:2015 | Volume:17 | Issue:3 (67) Page(s): 429-437

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Title

CELL ATTACHMENT AND PROLIFERATION OF HUMAN ADIPOSE-DERIVED STEM CELLS ON PLGA/CHITOSAN ELECTROSPUN NANO-BIOCOMPOSITE

Author(s)

Keywords

CHITOSAN

MESENCHYMAL STEM CELL

PLGA

SCAFFOLD

Abstract

Objective: In this study, nano-biocomposite composed of poly (lactide-co-glycolide) (PLGA) and CHITOSAN (CS) were electrospun through a single nozzle by dispersing the CS nano-powders in PLGA solution. The cellular behavior of human adipose derived stem cells (h-ADSCs) on random and aligned SCAFFOLDs was then evaluated.Materials and Methods: In this experimental study, the PLGA/CS SCAFFOLDs were prepared at the different ratios of 90/10, 80/20, and 70/30 (w/w) %. Morphology, cell adhesion and proliferation rate of h-ADSCs on the SCAFFOLDs were assessed using scanning electron microscope (SEM), 3- (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyl tetrazolium bromide (MTT) assay and trypan blue staining respectively.Results: H-ADSCs seeded on the matrices indicated that the PLGA/CS composite matrix with aligned nanofibres and higher content of CS nano-powders gave significantly better performance than others in terms of cell adhesion and proliferation rate (P<0.05).Conclusion: We found that CS enhanced cell adhesion and proliferation rate, and aligned nanofibers guided cell growth along the longitudinal axis of the nanofibers, which would provide a beneficial approach for tissue engineering.

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APA: Copy

RAZAVI, SHAHNAZ, KARBASI, SAEED, MORSHED, MOHAMMAD, ZARKESH ESFAHANI, HAMID, GOLOZAR, MOHAMMAD, & VAEZIFAR, SEDIGHEH. (2015). CELL ATTACHMENT AND PROLIFERATION OF HUMAN ADIPOSE-DERIVED STEM CELLS ON PLGA/CHITOSAN ELECTROSPUN NANO-BIOCOMPOSITE. CELL JOURNAL (YAKHTEH), 17(3 (67)), 429-437. SID. https://sid.ir/paper/660384/en

Vancouver: Copy

RAZAVI SHAHNAZ, KARBASI SAEED, MORSHED MOHAMMAD, ZARKESH ESFAHANI HAMID, GOLOZAR MOHAMMAD, VAEZIFAR SEDIGHEH. CELL ATTACHMENT AND PROLIFERATION OF HUMAN ADIPOSE-DERIVED STEM CELLS ON PLGA/CHITOSAN ELECTROSPUN NANO-BIOCOMPOSITE. CELL JOURNAL (YAKHTEH)[Internet]. 2015;17(3 (67)):429-437. Available from: https://sid.ir/paper/660384/en

IEEE: Copy

SHAHNAZ RAZAVI, SAEED KARBASI, MOHAMMAD MORSHED, HAMID ZARKESH ESFAHANI, MOHAMMAD GOLOZAR, and SEDIGHEH VAEZIFAR, “CELL ATTACHMENT AND PROLIFERATION OF HUMAN ADIPOSE-DERIVED STEM CELLS ON PLGA/CHITOSAN ELECTROSPUN NANO-BIOCOMPOSITE,” CELL JOURNAL (YAKHTEH), vol. 17, no. 3 (67), pp. 429–437, 2015, [Online]. Available: https://sid.ir/paper/660384/en

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