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Information Journal Paper

Title

PREVALENCE OF ETV6/RUNX1 FUSION GENE IN PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN IRAN

Pages

  681-686

Abstract

 Objective: ETV6/RUNX1 (also known as TEL/AML1) is the most frequent gene fusion in childhood ACUTE LYMPHOBLASTIC LEUKEMIA (ALL). Sixty-three patients were enrolled in this study to explore the distribution of this gene in Iranian population.Methods: This study used 63 peripheral blood and bone marrow (PB/BM) samples from children with ALL.Immunophenotyping of PB and BM samples were performed using flow cytometry to illustrate the lineage. Moreover, REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION (RT-PCR) technique was used to amplify transcripts of leukemia-specific chromosome fusion gene ETV6/RUNX1 and to monitor the expression levels of the ETV6/RUNX1 in patients according to Van Dongen et al protocol.Findings: On the basis of French-American-British (FAB) classification, 47 individuals had ALL-L1. The incidence of ETV6/RUNX1 FUSION gene in this study was 34.9%. The laboratory and clinical features of twenty two ETV6/RUNX1 positive ALL cases were similar to those of other studies. The most positive cases of ETV6/RUNX1 FUSION gene had the early pre B ALL and pre B ALL immunophenotypes.Conclusion: The ETV6/RUNX1 FUSION gene is a common genetic anomaly in Iranian childhood ALL patients and the prevalence of the ETV6/RUNX1 FUSION gene is similar to that of ALL patients in other countries. However early pre B cells were the most common type in studied patients.

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    • Cite

    APA: Copy

    RAHNEMOON, AHMAD REZA, ZAKER, FARHAD, IZADYAR, MINA, ANSARI, SHAHLA, POOPAK, BEHZAD, & TADAVOSYAN, YURI. (2013). PREVALENCE OF ETV6/RUNX1 FUSION GENE IN PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN IRAN. IRANIAN JOURNAL OF PEDIATRICS, 23(6), 681-686. SID. https://sid.ir/paper/660685/en

    Vancouver: Copy

    RAHNEMOON AHMAD REZA, ZAKER FARHAD, IZADYAR MINA, ANSARI SHAHLA, POOPAK BEHZAD, TADAVOSYAN YURI. PREVALENCE OF ETV6/RUNX1 FUSION GENE IN PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN IRAN. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2013;23(6):681-686. Available from: https://sid.ir/paper/660685/en

    IEEE: Copy

    AHMAD REZA RAHNEMOON, FARHAD ZAKER, MINA IZADYAR, SHAHLA ANSARI, BEHZAD POOPAK, and YURI TADAVOSYAN, “PREVALENCE OF ETV6/RUNX1 FUSION GENE IN PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN IRAN,” IRANIAN JOURNAL OF PEDIATRICS, vol. 23, no. 6, pp. 681–686, 2013, [Online]. Available: https://sid.ir/paper/660685/en

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