EFFECT OF CROCUS SATIVUS EXTRACTS AND ITS ACTIVE CONSTITUENT SAFRANAL ON THE HARMALINE-INDUCED TREMOR IN MICE

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AMIN BAHAREH; MALEKZADEH MAHSHAD; HEIDARI MAHMOUD REZA; HOSSEINZADEH HOSSEIN

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2015 | Volume:18 | Issue:5 Page(s): 449-458

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Title

EFFECT OF CROCUS SATIVUS EXTRACTS AND ITS ACTIVE CONSTITUENT SAFRANAL ON THE HARMALINE-INDUCED TREMOR IN MICE

Author(s)

AMIN BAHAREH | MALEKZADEH MAHSHAD | HEIDARI MAHMOUD REZA | HOSSEINZADEH HOSSEIN | Issue Writer Certificate

Keywords

CROCUS SATIVUS

ESSENTIAL TREMOR

HARMALINE

SAFRANAL

Abstract

Objective(s): Due to unsatisfactory response or intolerable side effects of current drugs, treatment of ESSENTIAL TREMOR remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of CROCUS SATIVUS (saffron), and its active consistent, SAFRANAL, on the HARMALINE-induced tremor in mice.Materials and Methods: To induce tremor, HARMALINE (30 mg/kg) was injected intraperitoneally. Test groups were also given the aqueous and ethanolic extracts of saffron (40, 80, and 160 mg/kg) as well as SAFRANAL (0.1, 0.3, and 0.5 ml/kg), intraperitoneally, 10 min before HARMALINE administration (prophylactic study) or 10 min after the onset of tremors (curative study). The latency of onset, duration, and intensity of tremor were recorded.Results: The extracts (80 and160 mg/kg) dose dependently attenuated duration of HARMALINE-induced tremors as did reference drug, propranolol (2 and 5 mg/kg). Only the highest dose of extracts (160 mg/kg) attenuated intensity of HARMALINE-induced tremors throughout the study. SAFRANAL at the doses of (0.1 and 0.3 ml/kg) but not 0.5 ml/kg attenuated duration and intensity of tremor. Onset of tremor increased with the extracts (80 and 160 mg/kg) in prophylactic study, as the effect observed with propranolol at the dose of 5 mg/kg. SAFRANAL did not affect the latency of tremor.Conclusion: Both aqueous and ethanolic extracts of saffron and with a less effect, low doses of SAFRANAL, have relatively protective and suppressive effects on the HARMALINE-induced tremor and different constituents of extracts seem to participate in the protective effects against HARMALINE induced tremor.

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APA: Copy

AMIN, BAHAREH, MALEKZADEH, MAHSHAD, HEIDARI, MAHMOUD REZA, & HOSSEINZADEH, HOSSEIN. (2015). EFFECT OF CROCUS SATIVUS EXTRACTS AND ITS ACTIVE CONSTITUENT SAFRANAL ON THE HARMALINE-INDUCED TREMOR IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(5), 449-458. SID. https://sid.ir/paper/665268/en

Vancouver: Copy

AMIN BAHAREH, MALEKZADEH MAHSHAD, HEIDARI MAHMOUD REZA, HOSSEINZADEH HOSSEIN. EFFECT OF CROCUS SATIVUS EXTRACTS AND ITS ACTIVE CONSTITUENT SAFRANAL ON THE HARMALINE-INDUCED TREMOR IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(5):449-458. Available from: https://sid.ir/paper/665268/en

IEEE: Copy

BAHAREH AMIN, MAHSHAD MALEKZADEH, MAHMOUD REZA HEIDARI, and HOSSEIN HOSSEINZADEH, “EFFECT OF CROCUS SATIVUS EXTRACTS AND ITS ACTIVE CONSTITUENT SAFRANAL ON THE HARMALINE-INDUCED TREMOR IN MICE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 5, pp. 449–458, 2015, [Online]. Available: https://sid.ir/paper/665268/en

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