EFFECT OF ACETYLCHOLINE RECEPTORS ON THE PAIN‐RELATED ELECTRICAL ACTIVITIES IN THE HIPPOCAMPAL CA3 REGION OF MORPHINEADDICTED RATS

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LI GUAN ZENG; LIU ZHE HUI; WEI XINYA; ZHAO PAN; YANG CHUN XIAO; XU MAN YING

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Journal: Iranian Journal of Basic Medical Sciences Year:2015 | Volume:18 | Issue:7 Page(s): 664-671

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Title

EFFECT OF ACETYLCHOLINE RECEPTORS ON THE PAIN‐RELATED ELECTRICAL ACTIVITIES IN THE HIPPOCAMPAL CA3 REGION OF MORPHINEADDICTED RATS

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Keywords

HIPPOCAMPAL CA3

MORPHINE ADDICTION

MUSCARINERGIC

ACETYLCHOLINE RECEPTORS

PAIN

Abstract

Objective (s): To determine the effect of acetylcholine (ACh), pilocarpine, and atropine on PAIN evoked responses of PAIN excited neurons (PEN) and PAIN inhibited neurons (PIN) in HIPPOCAMPAL CA3 region of morphine addicted rats.Materials and Methods: Female Wistar rats, weighing between 230‐260 g were used in this study.Morphine addicted rats were generated by subcutaneous injection of increasing concentrations of morphine hydrochloride for six days. Trains of electrical impulses applied to the sciatic nerve were used as noxious stimulation and the evoked electrical activities of PEN or PIN in HIPPOCAMPAL CA3 area were recorded using extracellular electrophysiological recording techniques in hippocampal slices.The effect of acetylcholine receptor stimulation by ACh, the muscarinic agonist pilocarpine, and the muscarinic antagonist atropine on the PAIN evoked responses of PAIN related electrical activities was analyzed in HIPPOCAMPAL CA3 area of morphine addicted rats.Results: Intra‐CA3 microinjection of ACh (2 mg/1 ml) or pilocarpine (2 mg/1 ml) decreased the discharge frequency and prolonged the firing latency of PEN, but increased the discharge frequency and shortened the firing inhibitory duration (ID) of PIN. The intra‐CA3 administration of atropine (0.5 mg/1ml) produced opposite effect. The peak activity of cholinergic modulators was 2 to 4 min later in morphine addicted rats compared to peak activity previously observed in normal rats.Conclusion: ACh dependent modulation of noxious stimulation exists in HIPPOCAMPAL CA3 area of morphine addicted rats. Morphine treatment may shift the sensitivity of PAIN related neurons towards a delayed response to MUSCARINERGIC neurotransmission in HIPPOCAMPAL CA3 region.

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APA: Copy

LI, GUAN ZENG, LIU, ZHE HUI, WEI, XINYA, ZHAO, PAN, YANG, CHUN XIAO, & XU, MAN YING. (2015). EFFECT OF ACETYLCHOLINE RECEPTORS ON THE PAIN?RELATED ELECTRICAL ACTIVITIES IN THE HIPPOCAMPAL CA3 REGION OF MORPHINEADDICTED RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(7), 664-671. SID. https://sid.ir/paper/665285/en

Vancouver: Copy

LI GUAN ZENG, LIU ZHE HUI, WEI XINYA, ZHAO PAN, YANG CHUN XIAO, XU MAN YING. EFFECT OF ACETYLCHOLINE RECEPTORS ON THE PAIN?RELATED ELECTRICAL ACTIVITIES IN THE HIPPOCAMPAL CA3 REGION OF MORPHINEADDICTED RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(7):664-671. Available from: https://sid.ir/paper/665285/en

IEEE: Copy

GUAN ZENG LI, ZHE HUI LIU, XINYA WEI, PAN ZHAO, CHUN XIAO YANG, and MAN YING XU, “EFFECT OF ACETYLCHOLINE RECEPTORS ON THE PAIN?RELATED ELECTRICAL ACTIVITIES IN THE HIPPOCAMPAL CA3 REGION OF MORPHINEADDICTED RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 7, pp. 664–671, 2015, [Online]. Available: https://sid.ir/paper/665285/en

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