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Information Journal Paper

Title

VASCULAR ENDOTHELIAL GROWTH FACTOR -2578C/A POLYMORPHISM AND COLORECTAL CANCER RISK: A META-ANALYSIS

Pages

  811-817

Abstract

 Background: The effects of the VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) gene -2578C/A POLYMORPHISM on COLORECTAL CANCER (CRC) risk have been investigated in some studies; however, the results of these studies were conflicting and ambiguous. Therefore, we aimed to do a META-ANALYSIS to investigate the association of VEGF −2578C/A POLYMORPHISMs with CRC risk from all eligible case-control studies published to date.Materials and Methods: An electronic search of the PubMed, Embase and Medline was performed. Retrieve terms were utilized as following: (“VEGF a” [MeSH Terms]) and (“polymorphism, genetic” [MeSH Terms]) and (“colorectal neoplasms” [MeSH Terms]). The association between VEGF-2578C/A POLYMORPHISMs with CRC risk was calculated with odds ratios (ORs) and their corresponding 95% of confi dence intervals (CIs), and stratified analysis was also conducted with respect to ethnicity.Results: A comprehensive META-ANALYSIS of eight studies, including 2312 cases and 2308 controls was performed in this work. Combined analysis revealed that a significant association between the VEGF −2578C/A POLYMORPHISM with CRC risk was identified in three comparison models including C allele versus A allele (OR=0.85, 95% CI 0.75-0.97, P=0.02), AA versus CA+CC (OR=1.28, 95% CI 1.09-1.51, P=0.003), and AA versus CC (OR=0.77, 95% CI 0.64-0.93, P=0.006). Moreover, a similar result was obtained in the subgroup analysis that comparison models of C allele versus. A allele (OR=0.85, 95% CI 0.76-0.95, P=0.004), AA versus CA+CC (OR=1.31, 95% CI 1.09-1.57, P=0.004), and AA versus CC (OR=0.73, 95% CI 0.59-0.90, P=0.004) was confirmed to be associated with CRC risk in Caucasian.Conclusion: It has been proved that the C allele versus A allele, AA versus CA+CC, and AA versus CC comparison models of VEGF −2578C/A POLYMORPHISM might be risk factors for CRC, but further studies with larger sample sizes are required to make a better assessment of above association.

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    APA: Copy

    WANG, LEI, JI, SHAN, & CHENG, ZENENG. (2015). VASCULAR ENDOTHELIAL GROWTH FACTOR -2578C/A POLYMORPHISM AND COLORECTAL CANCER RISK: A META-ANALYSIS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 20(8), 811-817. SID. https://sid.ir/paper/665297/en

    Vancouver: Copy

    WANG LEI, JI SHAN, CHENG ZENENG. VASCULAR ENDOTHELIAL GROWTH FACTOR -2578C/A POLYMORPHISM AND COLORECTAL CANCER RISK: A META-ANALYSIS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2015;20(8):811-817. Available from: https://sid.ir/paper/665297/en

    IEEE: Copy

    LEI WANG, SHAN JI, and ZENENG CHENG, “VASCULAR ENDOTHELIAL GROWTH FACTOR -2578C/A POLYMORPHISM AND COLORECTAL CANCER RISK: A META-ANALYSIS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 20, no. 8, pp. 811–817, 2015, [Online]. Available: https://sid.ir/paper/665297/en

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