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Information Journal Paper

Title

THE EFFECT OF CHELIDONIUM MAJUS EXTRACT ON THE LIPID PROFILE AND ACTIVITY OF PITUITARY-GONADAL AXIS IN HYPERCHOLESTEROLEMIC RATS

Pages

  18-22

Abstract

 Background: Over the past centuries, global population has increased at different rates and so has been the case with cardiovascular diseases. Therefore, given the importance of population and CHOLESTEROL control, the purpose of this study is to investigate the effect of CHELIDONIUM MAJUS (C. majus) aerial parts extract on the lipid profile and PROLACTIN levels and the activity of pituitary-gonadal axis in hypercholesterolemic rats.Materials and Methods: In this experimental study, 35 Wistar rats were selected and categorized into 5 groups. The control group had ordinary diet, the model group had highfat diet, and experimental groups consisted of hypercholesterolemic rats that respectively received minimal dosages of 100, 200 and 300 mg/kg of C. majus extract. After 21 days, blood samples were taken and the factors of interest were measured. Then, the gathered data were analyzed using SPSS-11.5.Results: The amount of triglyceride and CHOLESTEROL were increased in the model group compared to the control group whereas the same items were decreased in the experimental group. C. majus extract also decreased TESTOSTERONE and increased PROLACTIN and GONADOTROPINS.Conclusion: In this study, C. majus extract resulted in decreased fat and TESTOSTERONE levels as well as increased PROLACTIN level; however, since many sources have informed of the toxicity of this plant, cautious use of the plant is advised.

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    APA: Copy

    ZAREI, ALI, CHANGIZI ASHTIYANI, SAEED, REZAEI, AZAM, SHEIDAEE, HASSAN, & NABIYONI, FATEMEH. (2014). THE EFFECT OF CHELIDONIUM MAJUS EXTRACT ON THE LIPID PROFILE AND ACTIVITY OF PITUITARY-GONADAL AXIS IN HYPERCHOLESTEROLEMIC RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 16(10), 18-22. SID. https://sid.ir/paper/665525/en

    Vancouver: Copy

    ZAREI ALI, CHANGIZI ASHTIYANI SAEED, REZAEI AZAM, SHEIDAEE HASSAN, NABIYONI FATEMEH. THE EFFECT OF CHELIDONIUM MAJUS EXTRACT ON THE LIPID PROFILE AND ACTIVITY OF PITUITARY-GONADAL AXIS IN HYPERCHOLESTEROLEMIC RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2014;16(10):18-22. Available from: https://sid.ir/paper/665525/en

    IEEE: Copy

    ALI ZAREI, SAEED CHANGIZI ASHTIYANI, AZAM REZAEI, HASSAN SHEIDAEE, and FATEMEH NABIYONI, “THE EFFECT OF CHELIDONIUM MAJUS EXTRACT ON THE LIPID PROFILE AND ACTIVITY OF PITUITARY-GONADAL AXIS IN HYPERCHOLESTEROLEMIC RATS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 16, no. 10, pp. 18–22, 2014, [Online]. Available: https://sid.ir/paper/665525/en

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