EFFICACY OF PREOPERATIVE CHEMOTHERAPY IN TREATMENT OF CHILDREN WITH WILMS’ TUMOR: A META-ANALYSIS

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JUNJUN JIA; XUELIAN ZHOU; DHRUBA KADEL; XIE HAIYANG; ZHOU LIN; ZHENG SHUSEN

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Journal: Iranian Journal of Pediatrics Year:2015 | Volume:25 | Issue:2 Page(s): 1-7

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Title

EFFICACY OF PREOPERATIVE CHEMOTHERAPY IN TREATMENT OF CHILDREN WITH WILMS’ TUMOR: A META-ANALYSIS

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Keywords

WILMS’ TUMOR

EVENT FREE SURVIVAL

META-ANALYSIS

Abstract

Context: To assess the efficacy of preoperative chemotherapy in WILMS’ TUMOR patients and explore its true value for specific subgroups.Objectives: In the presence of these controversies, a META-ANALYSIS that examines the efficacy of preoperative chemotherapy in WILMS’ TUMOR patients and specific subgroups is needed to clarify these issues. The objective of this META-ANALYSIS is to assess the efficacy of preoperative chemotherapy in WILMS’ TUMOR patients and explore its true value for specific subgroups.Data Sources: Computer-based systematic search with “preoperative chemotherapy”, “Neoadjuvant Therapy” and “WILMS’ TUMOR” as search terms till January 2013 was performed.Study Selection: No language restrictions were applied. Searches were limited to randomized clinical trials (RCTs) or retrospective studies in human participants under 18 years. A manual examination of references in selected articles was also performed.Data Extraction: Relative Risk (RR) and their 95% Confidence Interval (CI) for Tumor Shrinkage (TS), total Tumor Resection (TR), Event-Free Survival (EFS) and details of subgroup analysis were extracted. META-ANALYSIS was carried out with the help of the software STATA 11.0. Finally, four original Randomized Clinical Trials (RCTs) and 28 retrospective studies with 2375 patients were included.Results: For preoperative chemotherapy vs. up-front surgery (PC vs. SU) group, the pooled RR was 9.109 for TS (95% CI: 5.109 - 16.241; P<0.001), 1.291 for TR (95% CI: 1.124 - 1.483; P<0.001) and 1.101 for EFS (95% CI: 0.980 - 1.238; P=0.106). For subgroup short course vs. long course (SC vs. LC), the pooled RR was 1.097 for TS (95% CI: 0.784 - 1.563; P=0.587), 1.197 for TR (95% CI: 0.960 - 1.493; P=0.110) and 1.006 for EFS (95% CI: 0.910 - 1.250; P=0.430).Conclusions: Short course preoperative chemotherapy is as effective as long course and preoperative chemotherapy only benefits WILMS’ TUMOR patients in tumor shrinkage and resection but not event-free survival.

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APA: Copy

JUNJUN, JIA, XUELIAN, ZHOU, DHRUBA, KADEL, XIE, HAIYANG, ZHOU, LIN, & ZHENG, SHUSEN. (2015). EFFICACY OF PREOPERATIVE CHEMOTHERAPY IN TREATMENT OF CHILDREN WITH WILMS’ TUMOR: A META-ANALYSIS. IRANIAN JOURNAL OF PEDIATRICS, 25(2), 1-7. SID. https://sid.ir/paper/665615/en

Vancouver: Copy

JUNJUN JIA, XUELIAN ZHOU, DHRUBA KADEL, XIE HAIYANG, ZHOU LIN, ZHENG SHUSEN. EFFICACY OF PREOPERATIVE CHEMOTHERAPY IN TREATMENT OF CHILDREN WITH WILMS’ TUMOR: A META-ANALYSIS. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2015;25(2):1-7. Available from: https://sid.ir/paper/665615/en

IEEE: Copy

JIA JUNJUN, ZHOU XUELIAN, KADEL DHRUBA, HAIYANG XIE, LIN ZHOU, and SHUSEN ZHENG, “EFFICACY OF PREOPERATIVE CHEMOTHERAPY IN TREATMENT OF CHILDREN WITH WILMS’ TUMOR: A META-ANALYSIS,” IRANIAN JOURNAL OF PEDIATRICS, vol. 25, no. 2, pp. 1–7, 2015, [Online]. Available: https://sid.ir/paper/665615/en

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