مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ERADICATION OF HELICOBACTER PYLORI IN CHILDREN BY TRIPLE THERAPY REGIMENS OF AMOXICILLIN, OMEPRAZOLE, AND CLARITHROMYCIN OR AZITHROMYCIN

Pages

  0-0

Abstract

 Background and Objectives: The present study aimed to evaluate the effect of classical and azithromycin-containing triple therapy eradication regimen against H. Pylori in CHILDREN, and to determine the level of patients’ tolerance.Patients and Methods: This single clinical trial was performed in 2014 on 2 to 15 years old CHILDREN. All CHILDREN, in whom H. Pylori infection was confirmed through multiple biopsies of the stomach and required TREATMENT, were enrolled in the study. H. Pylori-positive patients were treated alternately with two different DRUG regimens; Group OCA received clarithromycin 7.5 mg/kg/day every 12 hours for 10 days, amoxicillin 50 mg/kg/day every 12 hours for 10 days, and omeprazole 1 mg/kg/day every 12 hours for two weeks, and Group OAA received azithromycin 10 mg/kg/day once a day (before meal) for 6 days along with amoxicillin and omeprazole. Four to six weeks after completion of TREATMENT, patients’ stool was tested for H. Pylori through the monoclonal method using the Helicobacter antigen quick kit.Results: There were no significant differences between the two groups regarding gender and age of patients. Based on ITT analysis, the therapeutic response in the OAA and OCA groups were 56.2% and 62.5%, respectively (P=0.40). DRUG adverse effects were 15.6% in the OCA and 3.1% in the OAA group (P=0.19).Conclusions: The therapeutic response was seen in more than half of the patients treated with triple therapy of H. Pylori eradication regimen including azithromycin or clarithromycin, and there was no significant difference between the two TREATMENT groups.

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    Cite

    APA: Copy

    ESMAEILI DOOKI, MOHAMMAD REZA, SHIRDEL, HOSSEIN, & HAJIAHMADI, MAHMOOD. (2015). ERADICATION OF HELICOBACTER PYLORI IN CHILDREN BY TRIPLE THERAPY REGIMENS OF AMOXICILLIN, OMEPRAZOLE, AND CLARITHROMYCIN OR AZITHROMYCIN. IRANIAN JOURNAL OF PEDIATRICS, 25(6), 0-0. SID. https://sid.ir/paper/665757/en

    Vancouver: Copy

    ESMAEILI DOOKI MOHAMMAD REZA, SHIRDEL HOSSEIN, HAJIAHMADI MAHMOOD. ERADICATION OF HELICOBACTER PYLORI IN CHILDREN BY TRIPLE THERAPY REGIMENS OF AMOXICILLIN, OMEPRAZOLE, AND CLARITHROMYCIN OR AZITHROMYCIN. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2015;25(6):0-0. Available from: https://sid.ir/paper/665757/en

    IEEE: Copy

    MOHAMMAD REZA ESMAEILI DOOKI, HOSSEIN SHIRDEL, and MAHMOOD HAJIAHMADI, “ERADICATION OF HELICOBACTER PYLORI IN CHILDREN BY TRIPLE THERAPY REGIMENS OF AMOXICILLIN, OMEPRAZOLE, AND CLARITHROMYCIN OR AZITHROMYCIN,” IRANIAN JOURNAL OF PEDIATRICS, vol. 25, no. 6, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/665757/en

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