مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

FREQUENCY OF HUMAN PAPILLOMAVIRUS GENOTYPES 6, 11, 16, 18 AND 31 IN PARAFFIN-EMBEDDED TISSUE SAMPLES OF INVASIVE BREAST CARCINOMA, NORTH- EAST OF IRAN

Pages

  192-198

Keywords

HUMAN PAPILLOMAVIRUS (HPV) 
POLYMERASE CHAIN REACTION (PCR) 

Abstract

 Background &Objective: BREAST CANCER is the most common female malignancy. Detection of DNA of human papillomaviruses (HPVs) in breast carcinomas suggests that the virus may play a role in the pathogenesis of this disease. The aim of this study was to evaluate the frequency of HPVs genotypes 6, 11, 16, 18 and 31 in paraffin-embedded tissue samples of invasive breast carcinomas. Methods: Three hundred and twenty six paraffin-embedded tissue samples of BREAST CANCER were studied. PCR was performed using specific primers for HPV genotypes.Results: Of total 206 (63.2%) samples positive for Beta-globin gene, 54 (26.2%) were HPV-positive and 152 (73.8%) were negative for HPV. Distribution of HPV genotypes were as follows: 19 (25.7%) were positive for genotype 11, 5 (6.8%) were positive for genotype 6; and 2 cases (2.7%) were positive for both genotypes 6 and 11. Samples were also screened for HPV genotypes 16, 18 and 31 but none was positive.Conclusion: The current study confirmed the association of HPV and BREAST CANCER. However, all samples were negative for high-risk HPV types 16, 18 and 31.

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    APA: Copy

    SALEHPOUR, MASOUMEH, TAYYEBI MEIBODI, NASER, TEIMOURPOUR, ROGHAYEH, GHORANI AZAM, ADEL, SEPAHI, SAMANEH, ROSTAMI, SINA, & MESHKAT, ZAHRA. (2015). FREQUENCY OF HUMAN PAPILLOMAVIRUS GENOTYPES 6, 11, 16, 18 AND 31 IN PARAFFIN-EMBEDDED TISSUE SAMPLES OF INVASIVE BREAST CARCINOMA, NORTH- EAST OF IRAN. IRANIAN JOURNAL OF PATHOLOGY (IJP), 10(3), 192-198. SID. https://sid.ir/paper/665981/en

    Vancouver: Copy

    SALEHPOUR MASOUMEH, TAYYEBI MEIBODI NASER, TEIMOURPOUR ROGHAYEH, GHORANI AZAM ADEL, SEPAHI SAMANEH, ROSTAMI SINA, MESHKAT ZAHRA. FREQUENCY OF HUMAN PAPILLOMAVIRUS GENOTYPES 6, 11, 16, 18 AND 31 IN PARAFFIN-EMBEDDED TISSUE SAMPLES OF INVASIVE BREAST CARCINOMA, NORTH- EAST OF IRAN. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2015;10(3):192-198. Available from: https://sid.ir/paper/665981/en

    IEEE: Copy

    MASOUMEH SALEHPOUR, NASER TAYYEBI MEIBODI, ROGHAYEH TEIMOURPOUR, ADEL GHORANI AZAM, SAMANEH SEPAHI, SINA ROSTAMI, and ZAHRA MESHKAT, “FREQUENCY OF HUMAN PAPILLOMAVIRUS GENOTYPES 6, 11, 16, 18 AND 31 IN PARAFFIN-EMBEDDED TISSUE SAMPLES OF INVASIVE BREAST CARCINOMA, NORTH- EAST OF IRAN,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 10, no. 3, pp. 192–198, 2015, [Online]. Available: https://sid.ir/paper/665981/en

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