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Information Journal Paper

Title

FLIXWEED VS. POLYETHYLENE GLYCOL IN THE TREATMENT OF CHILDHOOD FUNCTIONAL CONSTIPATION: A RANDOMIZED CLINICAL TRIAL

Pages

  1-6

Abstract

 Background: POLYETHYLENE GLYCOL (PEG) is often considered as the first-line treatment for functional CONSTIPATION in CHILDREN. DESCURAINIA SOPHIA (L.) Webb et Berth (D. sophia) is a safe recommended medicine in Iranian folk and Traditional Persian Medicine for the treatment of CONSTIPATION.Objectives: To clinically compare D. sophia with PEG 4000 (without electrolyte) in pediatric CONSTIPATION and to assess its efficacy and side effects.Patients and Methods: 120 patients aged 2 - 12 years with CONSTIPATION for at least 3 months were included in an 8 weeks lasting randomized controlled trial within two parallel-groups. CHILDREN received either PEG, 0.4 g/kg/day, or D. sophia seeds, 2 grams (for CHILDREN aged 2 - 4 years) and 3 grams (for those aged>4 years) per day.Results: A total of 109 patients completed the study (56 in D. sophia and 53 in PEG group). At the end of the study, 36 (64.3%) patients in D. sophia group and 29 (54.7%) in PEG group were out of Rome III criteria (P=0.205). Median weekly stool frequency in 0, 1, 2, 3 weeks of the treatment was found to be 2, 5, 5, 5 in D. sophia and 3, 4, 4, 5 in PEG group (P=0.139, 0.076, 0.844, 0.294), respectively. The number of patients who suffered flatulence was less (5, 8.9%) in D. sophia group as compared to PEG group (6, 11.3%) at the end of the trial (P=0.461). D. sophia taste was less tolerated.Conclusions: D. sophia is introduced as a cheap and available medication which can be applied as a safe alternative to conventional PEG in the management of pediatric chronic functional CONSTIPATION.

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    APA: Copy

    NIMROUZI, MAJID, SADEGHPOUR, OMID, IMANIEH, MOHAMMAD HADI, SHAMS ARDEKANI, MOHAMMADREZA, SALEHI, ALIREZA, MINAEI, MOHAMAD BAGHER, & ZARSHENAS, MOHAMMAD M.. (2015). FLIXWEED VS. POLYETHYLENE GLYCOL IN THE TREATMENT OF CHILDHOOD FUNCTIONAL CONSTIPATION: A RANDOMIZED CLINICAL TRIAL. IRANIAN JOURNAL OF PEDIATRICS, 25(2), 1-6. SID. https://sid.ir/paper/665988/en

    Vancouver: Copy

    NIMROUZI MAJID, SADEGHPOUR OMID, IMANIEH MOHAMMAD HADI, SHAMS ARDEKANI MOHAMMADREZA, SALEHI ALIREZA, MINAEI MOHAMAD BAGHER, ZARSHENAS MOHAMMAD M.. FLIXWEED VS. POLYETHYLENE GLYCOL IN THE TREATMENT OF CHILDHOOD FUNCTIONAL CONSTIPATION: A RANDOMIZED CLINICAL TRIAL. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2015;25(2):1-6. Available from: https://sid.ir/paper/665988/en

    IEEE: Copy

    MAJID NIMROUZI, OMID SADEGHPOUR, MOHAMMAD HADI IMANIEH, MOHAMMADREZA SHAMS ARDEKANI, ALIREZA SALEHI, MOHAMAD BAGHER MINAEI, and MOHAMMAD M. ZARSHENAS, “FLIXWEED VS. POLYETHYLENE GLYCOL IN THE TREATMENT OF CHILDHOOD FUNCTIONAL CONSTIPATION: A RANDOMIZED CLINICAL TRIAL,” IRANIAN JOURNAL OF PEDIATRICS, vol. 25, no. 2, pp. 1–6, 2015, [Online]. Available: https://sid.ir/paper/665988/en

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