INVESTIGATION OF H19/RSAI POLYMORPHISM IN CHILDREN WITH LOW BIRTH WEIGHT IN PERNAMBUCO, BRAZIL

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MAIA PAULA; SOUZA PAULO; ANGELO HILDSON DORNELAS; SANTOS IGOR; MARTINS DANYELLY; FILHO JOSE LIMA; MAIA MARIA MASCENA

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Journal: Iranian Journal of Pediatrics Year:2015 | Volume:25 | Issue:2 Page(s): 1-3

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Title

INVESTIGATION OF H19/RSAI POLYMORPHISM IN CHILDREN WITH LOW BIRTH WEIGHT IN PERNAMBUCO, BRAZIL

Author(s)

Keywords

BIRTH WEIGHT

INFANT LOW BIRTH WEIGHT

GENOTYPE

ALLELES

POLYMORPHISM GENETIC

Abstract

Background: H19 is a strong candidate gene for influencing BIRTH WEIGHT variation and is exclusively imprinted maternally. In an attempt to understand the relationship of this gene polymorphism with low BIRTH WEIGHT children, we investigated association of H19/RsaI polymorphism with low BIRTH WEIGHT and normal BIRTH WEIGHT in children and their mothers.Objectives: The aim of our study was to establish the association between H19 gene polymorphism and LW in children born in Pernambuco, state of Brazil.Patients and Methods: It were selected 89 children, 40 low BIRTH WEIGHT (LW) and 49 normal BIRTH WEIGHT (NW) and 71 mothers (40 mothers of newborns NW and 31 mothers of newborns LW) attended at Dom Malan Hospital, Petrolina, Pernambuco - Brazil. Peripheral blood samples were collected from patients and genomic DNA was extracted and detected by electrophoresis agarose gel, stained by Blue Green Loading Dye. DNA PCR amplification was done using the primers H1 (sense) and H3 (antisense). PCR products were digested with RsaI and electrophoresed on agarose gel stained by ethidium bromide. Statistical analyses were performed using the program BioEstat version 5.0.Results: The RsaI polymorphism in the H19 gene showed that GENOTYPE frequencies did not differ statistically between low BIRTH WEIGHT (AA=12.5%, AB=45%, BB=42.5%) and control (AA=8.6% AB=36.73%, BB=55.10% groups) and the allele frequencies were not significantly different (P=0.2897). We also did not observe any association between maternal H19 allele polymorphism and low BIRTH WEIGHT newborns (P=0.7799) or normal BIRTH WEIGHT children (P=0.8976).Conclusions: The small size of sample may be the explanation for these results; future studies with more patients are needed to confirm the effect of H19/RsaI polymorphism on BIRTH WEIGHT of LW newborns.

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APA: Copy

MAIA, PAULA, SOUZA, PAULO, ANGELO, HILDSON DORNELAS, SANTOS, IGOR, MARTINS, DANYELLY, FILHO, JOSE LIMA, & MAIA, MARIA MASCENA. (2015). INVESTIGATION OF H19/RSAI POLYMORPHISM IN CHILDREN WITH LOW BIRTH WEIGHT IN PERNAMBUCO, BRAZIL. IRANIAN JOURNAL OF PEDIATRICS, 25(2), 1-3. SID. https://sid.ir/paper/665989/en

Vancouver: Copy

MAIA PAULA, SOUZA PAULO, ANGELO HILDSON DORNELAS, SANTOS IGOR, MARTINS DANYELLY, FILHO JOSE LIMA, MAIA MARIA MASCENA. INVESTIGATION OF H19/RSAI POLYMORPHISM IN CHILDREN WITH LOW BIRTH WEIGHT IN PERNAMBUCO, BRAZIL. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2015;25(2):1-3. Available from: https://sid.ir/paper/665989/en

IEEE: Copy

PAULA MAIA, PAULO SOUZA, HILDSON DORNELAS ANGELO, IGOR SANTOS, DANYELLY MARTINS, JOSE LIMA FILHO, and MARIA MASCENA MAIA, “INVESTIGATION OF H19/RSAI POLYMORPHISM IN CHILDREN WITH LOW BIRTH WEIGHT IN PERNAMBUCO, BRAZIL,” IRANIAN JOURNAL OF PEDIATRICS, vol. 25, no. 2, pp. 1–3, 2015, [Online]. Available: https://sid.ir/paper/665989/en

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