THE RETN GENE RS1862513 POLYMORPHISM AS A NOVEL PREDISPOSING MARKER FOR FAMILIAL ACNE VULGARIS IN A PAKISTANI POPULATION

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HUSSAIN SABIR; FARAZ AHMAD; IQBAL TAHIR

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Journal: Iranian Journal of Basic Medical Sciences Year:2015 | Volume:18 | Issue:5 Page(s): 526-528

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Title

THE RETN GENE RS1862513 POLYMORPHISM AS A NOVEL PREDISPOSING MARKER FOR FAMILIAL ACNE VULGARIS IN A PAKISTANI POPULATION

Author(s)

HUSSAIN SABIR | FARAZ AHMAD | IQBAL TAHIR | Issue Writer Certificate

Keywords

ACNE

ASSOCIATION

GENE

POLYMORPHISM RESISTIN

Abstract

Resistin (RETN), recently found to be relevant to inflammation and inflammatory disorders. We, therefore, aimed to investigate the potential role of RETN GENE polymorphism in pathogenesis of ACNE vulgaris with familial history. We investigated the RETN-420C/G polymorphism in 180 patients with ACNE vulgaris and 180 healthy individuals in a case-control ASSOCIATION analysis. In this study, we also investigated the heritability of the RETN susceptible allele from 140 trio families with ACNE affected offspring. The genotyping was performed by polymerase chain reaction and direct DNA sequencing.The RETN-420C/G polymorphism was significantly associated with ACNE in patients compared with healthy controls (P=0.014). The minor allele G at -420 was more prevalent in cases vs. controls (P=0.002). The RETN-420C/G polymorphism was significantly associated with severity of ACNE vulgaris in patients (P=0.0097). The results of a transmission disequilibrium test revealed a significant ASSOCIATION between the RETN-420C/G polymorphism and ACNE vulgaris (P<0.001). For the first time in the literature, to our knowledge, we demonstrate a significant ASSOCIATION of the RETN-420C/G functional polymorphism with familial ACNE vulgaris.

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APA: Copy

HUSSAIN, SABIR, FARAZ, AHMAD, & IQBAL, TAHIR. (2015). THE RETN GENE RS1862513 POLYMORPHISM AS A NOVEL PREDISPOSING MARKER FOR FAMILIAL ACNE VULGARIS IN A PAKISTANI POPULATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(5), 526-528. SID. https://sid.ir/paper/667021/en

Vancouver: Copy

HUSSAIN SABIR, FARAZ AHMAD, IQBAL TAHIR. THE RETN GENE RS1862513 POLYMORPHISM AS A NOVEL PREDISPOSING MARKER FOR FAMILIAL ACNE VULGARIS IN A PAKISTANI POPULATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(5):526-528. Available from: https://sid.ir/paper/667021/en

IEEE: Copy

SABIR HUSSAIN, AHMAD FARAZ, and TAHIR IQBAL, “THE RETN GENE RS1862513 POLYMORPHISM AS A NOVEL PREDISPOSING MARKER FOR FAMILIAL ACNE VULGARIS IN A PAKISTANI POPULATION,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 5, pp. 526–528, 2015, [Online]. Available: https://sid.ir/paper/667021/en

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