مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

SHORT COMMUNICATION: THE EFFECT OF INTRATHECAL DELIVERY OF BONE MARROW STROMAL CELLS ON HIPPOCAMPAL NEURONS IN RAT MODEL OF ALZHEIMER’S DISEASE

Pages

  520-525

Abstract

 Objective (s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model.Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of β amyloid into the hippocampus for histological and immunohistochemical studies.Results: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons.Conclusion: Our results showed that BMSCs intratechal administration could be a promising method for treatment of Alzheimer’s disease in rat model.

Cites

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    APA: Copy

    EFTEKHARZADEH, MINA, NOBAKHT, MALIHEH, ALIZADEH, AKRAM, SOLEIMANI, MANSOOREH, HAJGHASEM, MAHMOOD, KORDESTANI SHARGH, BAHAREH, KARKUKI OSGUEI, NUSHIN, BEHNAM, BABAK, & SAMADIKUCHAKSARAEI, ALI. (2015). SHORT COMMUNICATION: THE EFFECT OF INTRATHECAL DELIVERY OF BONE MARROW STROMAL CELLS ON HIPPOCAMPAL NEURONS IN RAT MODEL OF ALZHEIMER’S DISEASE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(5), 520-525. SID. https://sid.ir/paper/667194/en

    Vancouver: Copy

    EFTEKHARZADEH MINA, NOBAKHT MALIHEH, ALIZADEH AKRAM, SOLEIMANI MANSOOREH, HAJGHASEM MAHMOOD, KORDESTANI SHARGH BAHAREH, KARKUKI OSGUEI NUSHIN, BEHNAM BABAK, SAMADIKUCHAKSARAEI ALI. SHORT COMMUNICATION: THE EFFECT OF INTRATHECAL DELIVERY OF BONE MARROW STROMAL CELLS ON HIPPOCAMPAL NEURONS IN RAT MODEL OF ALZHEIMER’S DISEASE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(5):520-525. Available from: https://sid.ir/paper/667194/en

    IEEE: Copy

    MINA EFTEKHARZADEH, MALIHEH NOBAKHT, AKRAM ALIZADEH, MANSOOREH SOLEIMANI, MAHMOOD HAJGHASEM, BAHAREH KORDESTANI SHARGH, NUSHIN KARKUKI OSGUEI, BABAK BEHNAM, and ALI SAMADIKUCHAKSARAEI, “SHORT COMMUNICATION: THE EFFECT OF INTRATHECAL DELIVERY OF BONE MARROW STROMAL CELLS ON HIPPOCAMPAL NEURONS IN RAT MODEL OF ALZHEIMER’S DISEASE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 5, pp. 520–525, 2015, [Online]. Available: https://sid.ir/paper/667194/en

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