مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ASSOCIATION BETWEEN MUTATIONS INGYRA AND PARC GENES OF ACINETOBACTER BAUMANNIICLINICAL ISOLATES AND CIPROFLOXACIN RESISTANCE

Pages

  623-626

Abstract

 Objective (s): We investigated the contribution of GYRA and PARC mutational mechanism in decreased ciprofloxacin susceptibility ofACINETOBACTER BAUMANNII isolated from BURN wound infections.Materials and Methods: Ciprofloxacin susceptibility of 50 A. baumannii isolates was evaluated by disk diffusion and agar dilution methods. PCR and sequencing were performed for detection of mutation in GYRAand PARC genes.Results: The 44 and 4 isolates of A. baumannii exhibited full and intermediate‐resistant to ciprofloxacin, respectively. Overall, the 42 isolates with double mutations ofgyrA and PARC genes showed a higher level of CIPROFLOXACIN RESISTANCE than the 3 isolates with single mutations ofgyrA or PARC.Conclusion: Simultaneous mutations in GYRA and PARC genes are expected to play a major role in highlevel fluoroquinolone resistance in A. baumannii; albeit a single mutation in DNA topoisomerase IV could occasionally be associated with intermediate‐resistance to these antimicrobials.

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    APA: Copy

    ARDEBILI, ABDOLLAH, RASTEGAR LARI, ABDOLAZIZ, BEHESHTI, MARYAM, & RASTEGAR LARI, ELNAZ. (2015). ASSOCIATION BETWEEN MUTATIONS INGYRA AND PARC GENES OF ACINETOBACTER BAUMANNIICLINICAL ISOLATES AND CIPROFLOXACIN RESISTANCE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(6), 623-626. SID. https://sid.ir/paper/667198/en

    Vancouver: Copy

    ARDEBILI ABDOLLAH, RASTEGAR LARI ABDOLAZIZ, BEHESHTI MARYAM, RASTEGAR LARI ELNAZ. ASSOCIATION BETWEEN MUTATIONS INGYRA AND PARC GENES OF ACINETOBACTER BAUMANNIICLINICAL ISOLATES AND CIPROFLOXACIN RESISTANCE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(6):623-626. Available from: https://sid.ir/paper/667198/en

    IEEE: Copy

    ABDOLLAH ARDEBILI, ABDOLAZIZ RASTEGAR LARI, MARYAM BEHESHTI, and ELNAZ RASTEGAR LARI, “ASSOCIATION BETWEEN MUTATIONS INGYRA AND PARC GENES OF ACINETOBACTER BAUMANNIICLINICAL ISOLATES AND CIPROFLOXACIN RESISTANCE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 6, pp. 623–626, 2015, [Online]. Available: https://sid.ir/paper/667198/en

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