PIGMENT EPITHELIUM‐DERIVED FACTOR: CLINICAL SIGNIFICANCE IN ESTROGEN‐DEPENDENT TISSUES AND ITS POTENTIAL IN CANCER THERAPY

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FRANCO CHUAIRE MARIA LILIANA; RAMIREZ CLAVIJO SANDRA; CHUAIRE NOACK LILIAN

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2015 | Volume:18 | Issue:9 Page(s): 837-855

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Title

PIGMENT EPITHELIUM‐DERIVED FACTOR: CLINICAL SIGNIFICANCE IN ESTROGEN‐DEPENDENT TISSUES AND ITS POTENTIAL IN CANCER THERAPY

Author(s)

FRANCO CHUAIRE MARIA LILIANA | RAMIREZ CLAVIJO SANDRA | CHUAIRE NOACK LILIAN | Issue Writer Certificate

Keywords

ANTI‐TUMORIGENESIS

ANTIANGIOGENESIS

ESTROGENS

ESTROGEN RECEPTORS

HORMONAL REGULATION

PEDF

SYNTHETIC PEPTIDES

Abstract

Pigment epithelium‐derived factor (PEDF) is a glycoprotein that belongs to the family of noninhibitory serpins. The broad spectrum of PEDF biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and antimetastatic properties. Although the structural domains of the PEDF gene that mediate such diverse effects and their mechanisms of action have not been completely elucidated, there is a large body of evidence describing their diverse range of activities; this evidence combined with the regulation of PEDF expression by sex steroids and their receptors have led to the idea that PEDF is not only a diagnostic and prognostic marker for certain diseases such as cancer, but is also a potential therapeutic target. In this manner, this paper aims to generally review the regulation of PEDF expression and PEDF interactions, as well as the findings that relate PEDF to the role of ESTROGENS and ESTROGEN RECEPTORS. In addition, this manuscript will review major advances toward potential therapeutic applications of PEDF.

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APA: Copy

FRANCO CHUAIRE, MARIA LILIANA, RAMIREZ CLAVIJO, SANDRA, & CHUAIRE NOACK, LILIAN. (2015). PIGMENT EPITHELIUM?DERIVED FACTOR: CLINICAL SIGNIFICANCE IN ESTROGEN?DEPENDENT TISSUES AND ITS POTENTIAL IN CANCER THERAPY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(9), 837-855. SID. https://sid.ir/paper/668245/en

Vancouver: Copy

FRANCO CHUAIRE MARIA LILIANA, RAMIREZ CLAVIJO SANDRA, CHUAIRE NOACK LILIAN. PIGMENT EPITHELIUM?DERIVED FACTOR: CLINICAL SIGNIFICANCE IN ESTROGEN?DEPENDENT TISSUES AND ITS POTENTIAL IN CANCER THERAPY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(9):837-855. Available from: https://sid.ir/paper/668245/en

IEEE: Copy

MARIA LILIANA FRANCO CHUAIRE, SANDRA RAMIREZ CLAVIJO, and LILIAN CHUAIRE NOACK, “PIGMENT EPITHELIUM?DERIVED FACTOR: CLINICAL SIGNIFICANCE IN ESTROGEN?DEPENDENT TISSUES AND ITS POTENTIAL IN CANCER THERAPY,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 9, pp. 837–855, 2015, [Online]. Available: https://sid.ir/paper/668245/en

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