INTRASPHINCTERIC BOTULINUM TOXIN INJECTION IN TREATMENT OF CHRONIC IDIOPATHIC CONSTIPATION IN CHILDREN

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AHMADI JAVAD; AZARY SAEEDEH; ASHJAEI BAHAR; PARAGOMI PEDRAM; KHALIFEH SOLTANI AMIN

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Journal Paper

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Journal: Iranian Journal of Pediatrics Year:2013 | Volume:23 | Issue:5 Page(s): 574-578

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Title

INTRASPHINCTERIC BOTULINUM TOXIN INJECTION IN TREATMENT OF CHRONIC IDIOPATHIC CONSTIPATION IN CHILDREN

Author(s)

Keywords

BOTULINUM TOXIN

BOTOX

CONSTIPATION

DEFECATION

CHILDREN

Abstract

Objective: Injection of BOTULINUM TOXIN into the anal sphincter is a novel and safe new treatment of chronic idiopathic CONSTIPATION and anal fissure in CHILDREN. The purpose of this study was to determine the utility of intra sphincteric injection of BOTOX in the treatment of CHILDREN with refractory CONSTIPATION.Methods: All CHILDREN who suffered from chronic CONSTIPATION for more than three months, and who had not responded to medical treatment, were referred to pediatrics surgical clinic for surgical intervention by pediatric gastroenterologist. The patients were randomly divided into cases and control group. The control group received no injection and was only treated with stool softeners. The case group received this therapy in addition to injection. After the BOTOX injection, patients were asked about the presence of the signs of CONSTIPATION including painful DEFECATION, vomiting, stool consistence, soiling and DEFECATION interval.Findings: DEFECATION of painful stool existed in 88% of patients before BOTOX injection and it was reduced to 15% after BOTOX injection. In the control group, 90% of patients had painful DEFECATION, which reduced to 86% after medical treatment (P=0.0001). Stool was hard in 80% of patients before was reduced to 28% after BOTOX injection. In the control group, it existed in 81% of CHILDREN and reduced to 78% after medical treatment (P=0.0001). Soiling existed in 62% of patients before and was reduced to 8% after BOTOX injection, but in the control group it reduced from 62 % to 42.5% after medical treatment (P=0.0001). In the control group, 98% of the patients had DEFECATION intervals more than 3 days and it was the same after medical treatment. In case group, this index before BOTOX injection was 9.1 days, and after BOTOX injection was reduced to 2.6 days (P=0.0001).Conclusion: Our study results showed that injection of BOTULINUM TOXIN into anal sphincter is an effective and safe new treatment of chronic idiopathic CONSTIPATION in CHILDREN.

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APA: Copy

AHMADI, JAVAD, AZARY, SAEEDEH, ASHJAEI, BAHAR, PARAGOMI, PEDRAM, & KHALIFEH SOLTANI, AMIN. (2013). INTRASPHINCTERIC BOTULINUM TOXIN INJECTION IN TREATMENT OF CHRONIC IDIOPATHIC CONSTIPATION IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS, 23(5), 574-578. SID. https://sid.ir/paper/669240/en

Vancouver: Copy

AHMADI JAVAD, AZARY SAEEDEH, ASHJAEI BAHAR, PARAGOMI PEDRAM, KHALIFEH SOLTANI AMIN. INTRASPHINCTERIC BOTULINUM TOXIN INJECTION IN TREATMENT OF CHRONIC IDIOPATHIC CONSTIPATION IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2013;23(5):574-578. Available from: https://sid.ir/paper/669240/en

IEEE: Copy

JAVAD AHMADI, SAEEDEH AZARY, BAHAR ASHJAEI, PEDRAM PARAGOMI, and AMIN KHALIFEH SOLTANI, “INTRASPHINCTERIC BOTULINUM TOXIN INJECTION IN TREATMENT OF CHRONIC IDIOPATHIC CONSTIPATION IN CHILDREN,” IRANIAN JOURNAL OF PEDIATRICS, vol. 23, no. 5, pp. 574–578, 2013, [Online]. Available: https://sid.ir/paper/669240/en

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