مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

308
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

109
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

ASSESSMENT OF ANTI HSV-1 ACTIVITY OF ALOE VERA GEL EXTRACT: AN IN VITRO STUDY

Pages

  49-54

Abstract

 Statement of the Problem: Herpes simplex virus (HSV) infection is one of the most common and debilitating oral diseases; yet, there is no standard topical treatment to control it. The extract of ALOE VERA leaves has been previously reported to have antiinflammatory, antibacterial, and also ANTIVIRAL effects. There is no data on anti-Herpes simplex virus type 1 (HSV-1) activity of ALOE VERA gel.Purpose: This study aimed to evaluate the anti-HSV-1 activity of ALOE VERA gel in Vero cell line.Materials and Method: In this study, gel extraction and cytotoxicity of various increasing concentrations of ALOE VERA gel (0.2, 0.5, 1, 2, and 5%) was evaluated in Dulbecco’s Modified Eagle Medium (DMEM) containing 2% fetal bovine serum (FBS). Having been washed with phosphate buffered saline, 50 plaque-forming units (PFU) of HSV-1 was added to each well. After 1 hour of incubation at 37°C, cell monolayers in 24 well plates were exposed to different increasing concentrations of ALOE VERA gel. The anti- HSV-1 activity of ALOE VERA gel in different concentrations was assessed by plaque reduction assays. Data were analyzed by using One-way ANOVA.Results: The cytotoxicity assay showed that ALOE VERA in prearranged concentrations was cell-compatible. The inhibitory effect of various concentrations of ALOE VERA was observed one hour after the Vero cell was infected with HSV-1. However, there was no significant difference between two serial concentrations (p>0.05). One-way ANOVA also revealed no significant difference between the groups. The findings indicated a dose-dependent ANTIVIRAL effect of ALOE VERA.Conclusion: The findings showed significant inhibitory effect of 0.2-5% ALOE VERA gel on HSV-1 growth in Vero cell line. Therefore, this gel could be a useful topical treatment for oral HSV-1 infections without any significant toxicity.

Cites

References

  • No record.

    • Cite

    APA: Copy

    REZAZADEH, FAHIMEH, MOSHAVERINIA, MARYAM, MOTAMEDIFAR, MOHAMMAD, & ALYASERI, MONTAZER. (2016). ASSESSMENT OF ANTI HSV-1 ACTIVITY OF ALOE VERA GEL EXTRACT: AN IN VITRO STUDY. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 17(1), 49-54. SID. https://sid.ir/paper/669904/en

    Vancouver: Copy

    REZAZADEH FAHIMEH, MOSHAVERINIA MARYAM, MOTAMEDIFAR MOHAMMAD, ALYASERI MONTAZER. ASSESSMENT OF ANTI HSV-1 ACTIVITY OF ALOE VERA GEL EXTRACT: AN IN VITRO STUDY. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2016;17(1):49-54. Available from: https://sid.ir/paper/669904/en

    IEEE: Copy

    FAHIMEH REZAZADEH, MARYAM MOSHAVERINIA, MOHAMMAD MOTAMEDIFAR, and MONTAZER ALYASERI, “ASSESSMENT OF ANTI HSV-1 ACTIVITY OF ALOE VERA GEL EXTRACT: AN IN VITRO STUDY,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 17, no. 1, pp. 49–54, 2016, [Online]. Available: https://sid.ir/paper/669904/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button