An Investigation of Post-radiation Gene Expression Profiles: A System Biology Study

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VAFAEE REZA; NIKZAMIR ABDOLRAHIM; RAZAGHI MOHAMMAD REZA; Rezaei Tavirani Sina; AHMADZADEH ALIREZA; EMAMHADI MOHAMMADALI

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Journal: JOURNAL OF LASERS IN MEDICAL SCIENCES Year:2020 | Volume:11 | Issue:suppl1 Page(s): 101-106

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Title

An Investigation of Post-radiation Gene Expression Profiles: A System Biology Study

Author(s)

Keywords

Radiation

Bioinformatics

Gene expression

Pathway

Dysregulation

Abstract

Introduction: Genomics and Bioinformatics are useful methods for exploring unclear aspects of Radiation effects on biological systems. Many Radiation-induced alterations in irradiated samples are post-Radiation time-dependent. This study aims to evaluate the post-irRadiation effects of the gamma ray on human Jurkat cells. Methods: Gene expression profiles of the samples harvested 6 and 24 hours after Radiation to find the critical differential expressed genes and the related Pathways. Samples are provided from Gene expression Omnibus (GEO) and analyzed by ClueGO. Results: Twnety-nine critical genes were determined as the important affected genes and 7 classes of related Pathways were introduced. CCNE2, PSMD11, CDC25C, ANAPC1, PLK1, AURKA, and CCNB1 that were associated with more than 6 Pathways were related to one of the determined Pathway groups. Conclusion: Cell protecting Pathways were associated with the genes (HSPA5, HSPA8, HSP90B1, HMMR, CEBPB, RXRA, and PSMD11) which were related to the minimum numbers of Pathways. The finding of this study corresponds to repair processes which depend on post-Radiation time. It seems these sets of genes are suitable candidates for further investigation.

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APA: Copy

VAFAEE, REZA, NIKZAMIR, ABDOLRAHIM, RAZAGHI, MOHAMMAD REZA, Rezaei Tavirani, Sina, AHMADZADEH, ALIREZA, & EMAMHADI, MOHAMMADALI. (2020). An Investigation of Post-radiation Gene Expression Profiles: A System Biology Study. JOURNAL OF LASERS IN MEDICAL SCIENCES, 11(suppl1), 101-106. SID. https://sid.ir/paper/671145/en

Vancouver: Copy

VAFAEE REZA, NIKZAMIR ABDOLRAHIM, RAZAGHI MOHAMMAD REZA, Rezaei Tavirani Sina, AHMADZADEH ALIREZA, EMAMHADI MOHAMMADALI. An Investigation of Post-radiation Gene Expression Profiles: A System Biology Study. JOURNAL OF LASERS IN MEDICAL SCIENCES[Internet]. 2020;11(suppl1):101-106. Available from: https://sid.ir/paper/671145/en

IEEE: Copy

REZA VAFAEE, ABDOLRAHIM NIKZAMIR, MOHAMMAD REZA RAZAGHI, Sina Rezaei Tavirani, ALIREZA AHMADZADEH, and MOHAMMADALI EMAMHADI, “An Investigation of Post-radiation Gene Expression Profiles: A System Biology Study,” JOURNAL OF LASERS IN MEDICAL SCIENCES, vol. 11, no. suppl1, pp. 101–106, 2020, [Online]. Available: https://sid.ir/paper/671145/en

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