مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

TRANSPLANTATION OF ADULT MONKEY NEURAL STEM CELLS INTO A CONTUSION SPINAL CORD INJURY MODEL IN RHESUS MACAQUE MONKEYS

Pages

  117-130

Abstract

 Objective: Currently, cellular TRANSPLANTATION for spinal cord injuries (SCI) is the subject of numerous preclinical studies. Among the many cell types in the adult brain, there is a unique subpopulation of NEURAL STEM CELLs (NSC) that can self-renew and differentiate into neurons. The study aims, therefore, to explore the efficacy of adult monkey NSC (mNSC) in a primate SCI model.Materials and Methods: In this experimental study, isolated mNSCs were analyzed by flow cytometry, immunocytochemistry, and RT-PCR. Next, BrdU-labeled cells were transplanted into a SCI model. The SCI animal model was confirmed by magnetic resonance imaging (MRI) and histological analysis. Animals were clinically observed for 6 months.Results: Analysis confirmed homing of mNSCs into the injury site. Transplanted cells expressed neuronal markers (TubIII). Hind limb performance improved in transplanted animals based on Tarlov's scale and our established behavioral tests for monkeys.Conclusion: Our findings have indicated that mNSCs can facilitate recovery in contusion SCI models in rhesus macaque monkeys. Additional studies are necessary to determine the improvement mechanisms after cell TRANSPLANTATION.

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    Cite

    APA: Copy

    NEMATI, SHIVA, JABBARI, REZA, HAJINASROLLAH, MOSTAFA, ZARE MEHRJERDI, NARGESS, AZIZI, HOSSEIN, HEMMESI, KATAYOUN, MOGHIMINASR, REZA, AZHDARI, ZAHRA, TALEBI, ARDESHIR, MOHITMAFI, SOROUSH, VOSOUGH TAQI DIZAJ, AHMAD, SHARIFI, GIUVE, BAHARVAND, HOSSEIN, REZAEE, OMIDVAR, & KIANI, SAHAR. (2014). TRANSPLANTATION OF ADULT MONKEY NEURAL STEM CELLS INTO A CONTUSION SPINAL CORD INJURY MODEL IN RHESUS MACAQUE MONKEYS. CELL JOURNAL (YAKHTEH), 16(2 (62)), 117-130. SID. https://sid.ir/paper/672154/en

    Vancouver: Copy

    NEMATI SHIVA, JABBARI REZA, HAJINASROLLAH MOSTAFA, ZARE MEHRJERDI NARGESS, AZIZI HOSSEIN, HEMMESI KATAYOUN, MOGHIMINASR REZA, AZHDARI ZAHRA, TALEBI ARDESHIR, MOHITMAFI SOROUSH, VOSOUGH TAQI DIZAJ AHMAD, SHARIFI GIUVE, BAHARVAND HOSSEIN, REZAEE OMIDVAR, KIANI SAHAR. TRANSPLANTATION OF ADULT MONKEY NEURAL STEM CELLS INTO A CONTUSION SPINAL CORD INJURY MODEL IN RHESUS MACAQUE MONKEYS. CELL JOURNAL (YAKHTEH)[Internet]. 2014;16(2 (62)):117-130. Available from: https://sid.ir/paper/672154/en

    IEEE: Copy

    SHIVA NEMATI, REZA JABBARI, MOSTAFA HAJINASROLLAH, NARGESS ZARE MEHRJERDI, HOSSEIN AZIZI, KATAYOUN HEMMESI, REZA MOGHIMINASR, ZAHRA AZHDARI, ARDESHIR TALEBI, SOROUSH MOHITMAFI, AHMAD VOSOUGH TAQI DIZAJ, GIUVE SHARIFI, HOSSEIN BAHARVAND, OMIDVAR REZAEE, and SAHAR KIANI, “TRANSPLANTATION OF ADULT MONKEY NEURAL STEM CELLS INTO A CONTUSION SPINAL CORD INJURY MODEL IN RHESUS MACAQUE MONKEYS,” CELL JOURNAL (YAKHTEH), vol. 16, no. 2 (62), pp. 117–130, 2014, [Online]. Available: https://sid.ir/paper/672154/en

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