EFFECTS OF SILYMARIN ON NEUROPATHIC PAIN AND FORMALININDUCED NOCICEPTION IN MICE

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VAHDATI HASSANI FAEZEH; REZAEE RAMIN; SAZEGARA HASAN; HASHEMZAEI MAHMOUD; SHIRANI KOBRA; KARIMI GHOLAMREZA

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Journal: Iranian Journal of Basic Medical Sciences Year:2015 | Volume:18 | Issue:7 Page(s): 715-720

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Title

EFFECTS OF SILYMARIN ON NEUROPATHIC PAIN AND FORMALININDUCED NOCICEPTION IN MICE

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Keywords

SILYMARIN

FORMALIN TEST

SCIATIC NERVE LIGATION

INFLAMMATORY PAIN

Abstract

Objective (s): Based on the previous reports, SILYMARIN can suppress nitric oxide, prostaglandin E2 (PGE2), leukotrienes, cytokines production, and neutrophils infiltration. Regarding the fact that inflammation plays an important role in neuropathic and formalin‐induced pain, it was assumed that SILYMARIN could reduce pain. The present study investigates the analgesic effects of SILYMARIN in chemical nociception and a model of neuropathic pain.Materials and Methods: Chemical nociception was produced by injection of 20 μl of formalin (0.5% formaldehyde in saline) into the plantar region of the right hind paw. A sciatic‐nerve ligated mouse was applied as the model of neuropathic pain and the antinociceptive response of SILYMARIN was examined 14 days after unilateral nerve‐ligation using the hot plate test.Results: The intraperitoneal administration of SILYMARIN (25, 50, and, 100 mg/kg) 2 hr prior to the intraplantar formalin injection suppressed the nociceptive response during the late phase of the FORMALIN TEST significantly, but it was not in a dose‐dependent manner. Different doses of SILYMARIN 14 days after unilateral SCIATIC NERVE LIGATION in hot plate test did not induce obvious antinociception.Conclusion: Results of the present study indicated that repeated administration of SILYMARIN prevents the formalin‐induced nociceptive behavior. However, it is not effective in the treatment of sciatic neuropathic pain.

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APA: Copy

VAHDATI HASSANI, FAEZEH, REZAEE, RAMIN, SAZEGARA, HASAN, HASHEMZAEI, MAHMOUD, SHIRANI, KOBRA, & KARIMI, GHOLAMREZA. (2015). EFFECTS OF SILYMARIN ON NEUROPATHIC PAIN AND FORMALININDUCED NOCICEPTION IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(7), 715-720. SID. https://sid.ir/paper/672765/en

Vancouver: Copy

VAHDATI HASSANI FAEZEH, REZAEE RAMIN, SAZEGARA HASAN, HASHEMZAEI MAHMOUD, SHIRANI KOBRA, KARIMI GHOLAMREZA. EFFECTS OF SILYMARIN ON NEUROPATHIC PAIN AND FORMALININDUCED NOCICEPTION IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(7):715-720. Available from: https://sid.ir/paper/672765/en

IEEE: Copy

FAEZEH VAHDATI HASSANI, RAMIN REZAEE, HASAN SAZEGARA, MAHMOUD HASHEMZAEI, KOBRA SHIRANI, and GHOLAMREZA KARIMI, “EFFECTS OF SILYMARIN ON NEUROPATHIC PAIN AND FORMALININDUCED NOCICEPTION IN MICE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 7, pp. 715–720, 2015, [Online]. Available: https://sid.ir/paper/672765/en

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