SERUM ANTI-INFLAMMATORY CYTOKINES FOR THE EVALUATION OF INFLAMMATORY STATUS IN ENDOMETRIOSIS

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MALUŢAN ANDREI MIHAI; DRUGAN TUDOR; CIORTEA RAZVAN; MOCAN HOGNOGI RADU FLORIN; BUCURI CARMEN; RADA MARIA PATRICIA; MIHU DAN

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2015 | Volume:20 | Issue:7 Page(s): 668-674

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Title

SERUM ANTI-INFLAMMATORY CYTOKINES FOR THE EVALUATION OF INFLAMMATORY STATUS IN ENDOMETRIOSIS

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Keywords

CYTOKINES

ENDOMETRIOSIS

IMMUNITY

INFLAMMATION

INTERLEUKIN

Abstract

Background: ENDOMETRIOSIS is a frequent gynecologic disease with a severe impact on the quality of life in the affected women; its pathogenesis is yet to be fully understood, with an altered IMMUNITY as a possible key factor. The present study aimed to investigate the serum anti-inflammatory cytokine profile in the patients with ENDOMETRIOSIS compared with the healthy controls.Materials and Methods: One hundred and sixty women were included, divided into two study groups (Group I- ENDOMETRIOSIS; Group 2- healthy women). We evaluated the serum levels of INTERLEUKIN-1 receptor antagonist (IL-1Ra), IL-2, IL-2R, IL-4, IL-10, IL-13, and IL-15 with the use of Human multiplex cytokine panels. Statistical analyses (normality distribution analysis, independent t-test, Mann-Whitney U-test) were performed using IBM SPSS software (version 22.0) and GraphPad Prism (version 5.00); receiver operating characteristic curve were used to demonstrate the diagnostic performance of the studied markers. Results: The mean serum level of IL-1Ra, IL-4, and IL-10 were significantly higher in women with ENDOMETRIOSIS compared to women free of disease from the control group (30.155, 138.459, and 1.489, respectively, compared to 14.109, 84.710, and 0.688, respectively; P < 0.001, P < 0.001, and P = 0.002, respectively.). No significant differences in the mean serum levels of IL-2, IL-13, and IL-15 were observed between the studied groups and IL-2R had a very low detection rate. Conclusion: ENDOMETRIOSIS is associated with elevated levels of anti-inflammatory CYTOKINES, IL-1Ra, IL-4, and IL-10, markers that have a potential role as a prognostic factor for ENDOMETRIOSIS.

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APA: Copy

MALU?AN, ANDREI MIHAI, DRUGAN, TUDOR, CIORTEA, RAZVAN, MOCAN HOGNOGI, RADU FLORIN, BUCURI, CARMEN, RADA, MARIA PATRICIA, & MIHU, DAN. (2015). SERUM ANTI-INFLAMMATORY CYTOKINES FOR THE EVALUATION OF INFLAMMATORY STATUS IN ENDOMETRIOSIS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 20(7), 668-674. SID. https://sid.ir/paper/672770/en

Vancouver: Copy

MALU?AN ANDREI MIHAI, DRUGAN TUDOR, CIORTEA RAZVAN, MOCAN HOGNOGI RADU FLORIN, BUCURI CARMEN, RADA MARIA PATRICIA, MIHU DAN. SERUM ANTI-INFLAMMATORY CYTOKINES FOR THE EVALUATION OF INFLAMMATORY STATUS IN ENDOMETRIOSIS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2015;20(7):668-674. Available from: https://sid.ir/paper/672770/en

IEEE: Copy

ANDREI MIHAI MALU?AN, TUDOR DRUGAN, RAZVAN CIORTEA, RADU FLORIN MOCAN HOGNOGI, CARMEN BUCURI, MARIA PATRICIA RADA, and DAN MIHU, “SERUM ANTI-INFLAMMATORY CYTOKINES FOR THE EVALUATION OF INFLAMMATORY STATUS IN ENDOMETRIOSIS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 20, no. 7, pp. 668–674, 2015, [Online]. Available: https://sid.ir/paper/672770/en

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