Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective

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Saleem Sumaira; Muhammad Gulzar; Hussain Muhammad Ajaz; Altaf Muhammad; Abbas Bukhari Syed Nasir

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2020 | Volume:23 | Issue:12 Page(s): 1501-1526

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Title

Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective

Author(s)

Keywords

Clinical trials

Folk medicinal uses

Nutraceuticals

Pharmacological attributes

Phytonutrients

Withanolides

Abstract

Withania somnifera L. is a multipurpose medicinal plant of family Solanaceae occurring abundantly in sub-tropical regions of the world. The folk healers used the plant to treat several diseases such as fever, cancer, asthma, diabetes, ulcer, hepatitis, eyesores, arthritis, heart problems, and hemorrhoids. The plant is famous for the anti-cancerous activity, low back pain treatment, and muscle strengthening, which may be attributed to the withanolide alkaloids. W. somnifera is also rich in numerous valued secondary metabolites such as steroids, alkaloids, flavonoids, phenolics, saponins, and glycosides. A wide range of preClinical trials such as cardioprotective, anticancer, antioxidant, antibacterial, antifungal, anti-inflammatory, hepatoprotective, anti-depressant, and hypoglycemic have been attributed to various parts of the plant. Different parts of the plant have also been evaluated for the Clinical trials such as male infertility, obsessive-compulsive disorder, antianxiety, bone and muscle strengthening potential, hypolipidemic, and antidiabetic. This review focuses on Folk medicinal uses, phytochemistry, pharmacological, and nutrapharmaceutical potential of the versatile plant.

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APA: Copy

Saleem, Sumaira, Muhammad, Gulzar, Hussain, Muhammad Ajaz, Altaf, Muhammad, & Abbas Bukhari, Syed Nasir. (2020). Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 23(12), 1501-1526. SID. https://sid.ir/paper/674834/en

Vancouver: Copy

Saleem Sumaira, Muhammad Gulzar, Hussain Muhammad Ajaz, Altaf Muhammad, Abbas Bukhari Syed Nasir. Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2020;23(12):1501-1526. Available from: https://sid.ir/paper/674834/en

IEEE: Copy

Sumaira Saleem, Gulzar Muhammad, Muhammad Ajaz Hussain, Muhammad Altaf, and Syed Nasir Abbas Bukhari, “Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 23, no. 12, pp. 1501–1526, 2020, [Online]. Available: https://sid.ir/paper/674834/en

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