مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

GARDENIA JASMINOIDESEXTRACTS AND GALLIC ACID INHIBIT LIPOPOLYSACCHARIDE‐INDUCED INFLAMMATION BY SUPPRESSION OF JNK2/1 SIGNALING PATHWAYS IN BV‐2 CELLS

Pages

  555-562

Abstract

 Objective (s): GARDENIA JASMINOIDES Ellis (GJ, Cape Jasmine Fruit, Zhi Zi) has been traditionally used for the treatment of infectious hepatitis, aphthous ulcer, and trauma; however, the direct evidence is lacking.Materials and Methods: We investigated the effect of the GJ extract (GJ) and gallic acid (GA) on lipopolysaccharide (LPS) induced inflammation of BV‐2 microglial cells and acute liver injury in Sprague‐Dawley (SD) rats.Results: Our results showed that the GJ extract and GA reduced LPS‐induced nitric oxide (NO), interleukin (IL) ‐1, IL‐6, reactive oxygen species (ROS), and prostaglandin (PGE2) production in BV‐2 CELLs. The GJ extract and GA significantly decreased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in LPS‐treated rats. Furthermore, the water extract, but NOt the ethanol extract, of the GJ dose‐dependently inhibited LPS‐induced JNK2/1 and slightly p38 mitogenactivated protein kinases (MAPK), and cyclooxygenase‐2 (COX‐2) expression in BV‐2 CELLs.Conclusion: Taken together, these results indicate that the protective mechanism of the GJ extract involves an antioxidant effect and inhibition of JNK2/1 MAP kinase and COX‐2 expressions in LPSinduced inflammation of BV‐2 CELLs.

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    APA: Copy

    LIN, WEN HUNG, KUO, HENG HUNG, HO, LI HSING, TSENG, MING LANG, SIAO, AN CI, HUNG, CHANG TSEN, JENG, KEE CHING, & HOU, CHIEN WEI. (2015). GARDENIA JASMINOIDESEXTRACTS AND GALLIC ACID INHIBIT LIPOPOLYSACCHARIDE?INDUCED INFLAMMATION BY SUPPRESSION OF JNK2/1 SIGNALING PATHWAYS IN BV?2 CELLS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(6), 555-562. SID. https://sid.ir/paper/677869/en

    Vancouver: Copy

    LIN WEN HUNG, KUO HENG HUNG, HO LI HSING, TSENG MING LANG, SIAO AN CI, HUNG CHANG TSEN, JENG KEE CHING, HOU CHIEN WEI. GARDENIA JASMINOIDESEXTRACTS AND GALLIC ACID INHIBIT LIPOPOLYSACCHARIDE?INDUCED INFLAMMATION BY SUPPRESSION OF JNK2/1 SIGNALING PATHWAYS IN BV?2 CELLS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(6):555-562. Available from: https://sid.ir/paper/677869/en

    IEEE: Copy

    WEN HUNG LIN, HENG HUNG KUO, LI HSING HO, MING LANG TSENG, AN CI SIAO, CHANG TSEN HUNG, KEE CHING JENG, and CHIEN WEI HOU, “GARDENIA JASMINOIDESEXTRACTS AND GALLIC ACID INHIBIT LIPOPOLYSACCHARIDE?INDUCED INFLAMMATION BY SUPPRESSION OF JNK2/1 SIGNALING PATHWAYS IN BV?2 CELLS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 6, pp. 555–562, 2015, [Online]. Available: https://sid.ir/paper/677869/en

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