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Information Journal Paper

Title

DIFFERENCE IN TRANSIENT ISCHEMIA-INDUCED NEURONAL DAMAGE AND GLUCOSE TRANSPORTER-1 IMMUNOREACTIVITY IN THE HIPPOCAMPUS BETWEEN ADULT AND YOUNG GERBILS

Pages

  521-528

Abstract

 Objective (s): The alteration of glucose transporters is closely related with the pathogenesis of brain edema. We compared neuronal damage/death in the hippocampus between adult and YOUNG GERBILs following transient cerebral ischemia/reperfusion and changes of glucose transporter-1 (GLUT-1) -immunoreactive microvessels in their ischemic hippocampal CA1 REGION.Materials and Methods: Transient cerebral ischemia was developed by 5-min occlusion of both common carotid arteries. Neuronal damage was examined by cresyl violet staining, NeuN immunohistochemistry and Fluoro-Jade B histofluorescence staining and changes in GLUT-1 expression was carried out by immunohistochemistry.Results: About 90% of PYRAMIDAL NEURONS only in the adult CA1 REGION were damaged after ischemia/reperfusion; in the young, about 53 % of PYRAMIDAL NEURONS were damaged from 7 days after ischemia/reperfusion. The density of GLUT-1-immunoreactive microvessels was significantly higher in the young sham-group than that in the adult sham-group. In the ischemia-operated-groups, the density of GLUT-1-immunoreactive microvessels was significantly decreased in the adult and young at 1 and 4 days post-ischemia, respectively, thereafter, the density of GLUT-1-immunoreactive microvessels was gradually increased in both groups after ischemia/reperfusion.Conclusion: CA1 PYRAMIDAL NEURONS of the YOUNG GERBIL were damaged much later than that in the adult and that GLUT-1-immunoreactive microvessels were significantly decreased later in the young. These data indicate that GLUT-1 might differently contribute to neuronal damage according to age after ischemic insults.

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    APA: Copy

    PARK, SEUNG MIN, LEE, JAE CHUL, CHEN, BAI HUI, SHIN, BICH NA, CHO, JEONG HWI, KIM, IN HYE, PARK, JOON HA, WON, MOO HO, AHN, JI HYEON, TAE, HYUN JIN, SHIN, MYOUNG CHEOL, PARK, CHAN WOO, CHO, JUN HWI, & LEE, HUI YOUNG. (2016). DIFFERENCE IN TRANSIENT ISCHEMIA-INDUCED NEURONAL DAMAGE AND GLUCOSE TRANSPORTER-1 IMMUNOREACTIVITY IN THE HIPPOCAMPUS BETWEEN ADULT AND YOUNG GERBILS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(5), 521-528. SID. https://sid.ir/paper/678476/en

    Vancouver: Copy

    PARK SEUNG MIN, LEE JAE CHUL, CHEN BAI HUI, SHIN BICH NA, CHO JEONG HWI, KIM IN HYE, PARK JOON HA, WON MOO HO, AHN JI HYEON, TAE HYUN JIN, SHIN MYOUNG CHEOL, PARK CHAN WOO, CHO JUN HWI, LEE HUI YOUNG. DIFFERENCE IN TRANSIENT ISCHEMIA-INDUCED NEURONAL DAMAGE AND GLUCOSE TRANSPORTER-1 IMMUNOREACTIVITY IN THE HIPPOCAMPUS BETWEEN ADULT AND YOUNG GERBILS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(5):521-528. Available from: https://sid.ir/paper/678476/en

    IEEE: Copy

    SEUNG MIN PARK, JAE CHUL LEE, BAI HUI CHEN, BICH NA SHIN, JEONG HWI CHO, IN HYE KIM, JOON HA PARK, MOO HO WON, JI HYEON AHN, HYUN JIN TAE, MYOUNG CHEOL SHIN, CHAN WOO PARK, JUN HWI CHO, and HUI YOUNG LEE, “DIFFERENCE IN TRANSIENT ISCHEMIA-INDUCED NEURONAL DAMAGE AND GLUCOSE TRANSPORTER-1 IMMUNOREACTIVITY IN THE HIPPOCAMPUS BETWEEN ADULT AND YOUNG GERBILS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 5, pp. 521–528, 2016, [Online]. Available: https://sid.ir/paper/678476/en

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