Mechanisms of COVID-19 Entry into the Cell: Potential Therapeutic Approaches Based on Virus Entry Inhibition in COVID-19 Patients with Underlying Diseases

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MUSAVI HADIS; Abazari Omid; Safaee Mohamad Sadegh; Variji Atena; Koohshekan Bahare

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2021 | Volume:20 | Issue:1 Page(s): 11-23

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Title

Mechanisms of COVID-19 Entry into the Cell: Potential Therapeutic Approaches Based on Virus Entry Inhibition in COVID-19 Patients with Underlying Diseases

Author(s)

Keywords

Angiotensin

converting enzyme 2

COVID

SARS

COV

Therapeutics

Abstract

The Coronavirus disease 2019 (COVID/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">COVID-19) virus spread from Wuhan, China, in 2019 and is spreading rapidly around the world. COVID/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">COVID-19 victims are almost associated with cardiovascular disease, high blood pressure, diabetes, and other underlying diseases. Concerning the high prevalence of these disorders, widespread mortality threatens global society, and its fatality rate may increase with increasing COVID/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">COVID-19 prevalence in countries with older populations. Therefore, evaluating patients' clinical status with severe COVID/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">COVID-19 infection and their medical history can help manage treatment. Currently, one of the considered treatments is Angiotensin-converting enzyme 2 (ACE2) inhibition. This study investigated virus entry mechanisms through membrane receptors, their role in the pathogenesis of COVID/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">COVID-19 and underlying diseases, and treatment methods based on the viral entrance inhibition. According to existing studies, inhibition of ACE2 can increase oxidative stress, inflammation, fibrosis and ultimately exacerbate underlying diseases such as cardiovascular disease, kidney disease, diabetes, and hypertension in individuals with COVID/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">COVID-19. The ACE2 inhibition is not suitable for patients with COVID/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">COVID-19 with underlying diseases, but it seems that the recombinant ACE2 solution is more appropriate for inhibiting the virus in these patients if hypotension would be monitored.

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APA: Copy

MUSAVI, HADIS, Abazari, Omid, Safaee, Mohamad Sadegh, Variji, Atena, & Koohshekan, Bahare. (2021). Mechanisms of COVID-19 Entry into the Cell: Potential Therapeutic Approaches Based on Virus Entry Inhibition in COVID-19 Patients with Underlying Diseases. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 20(1), 11-23. SID. https://sid.ir/paper/678508/en

Vancouver: Copy

MUSAVI HADIS, Abazari Omid, Safaee Mohamad Sadegh, Variji Atena, Koohshekan Bahare. Mechanisms of COVID-19 Entry into the Cell: Potential Therapeutic Approaches Based on Virus Entry Inhibition in COVID-19 Patients with Underlying Diseases. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2021;20(1):11-23. Available from: https://sid.ir/paper/678508/en

IEEE: Copy

HADIS MUSAVI, Omid Abazari, Mohamad Sadegh Safaee, Atena Variji, and Bahare Koohshekan, “Mechanisms of COVID-19 Entry into the Cell: Potential Therapeutic Approaches Based on Virus Entry Inhibition in COVID-19 Patients with Underlying Diseases,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 20, no. 1, pp. 11–23, 2021, [Online]. Available: https://sid.ir/paper/678508/en

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