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Information Journal Paper

Title

Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity

Pages

  1603-1609

Abstract

 Objective(s): This study aimed to examine the effects of Genistein and Daidzein on Endometrial Receptivity by histopathological, immunohistochemical, and biochemical techniques. Materials and Methods: In this study, 72 female Sprague-Dawley Rats were randomly divided into 8 groups. The Endometrial Receptivity model was applied to identified groups. Experimental animals were given periorally 10 mg/kg and high 40 mg/kg doses of Genistein and Daidzein for 5 days by gavage. At the end of the experiment, uterine tissues were evaluated histopathologically, immunohistochemically, and biochemically. Results: When histopathological findings were examined, significant decreases in pinopod formation were observed in high dose Genistein and Daidzein groups. When compared with the Endometrial Receptivity group, immunohistochemical staining findings showed a significant decrease in the expression of integrin β 3, integrin α vβ 3, LIF, and HOXA10 and an increase in MUC 1 expression in the high dose of Genistein and Daidzein groups. In biochemical evaluations, it was determined that Genistein and Daidzein increased estrogen levels and decreased progesterone levels in a dosedependent manner. Conclusion: Genistein and Daidzein have a negative effect on Endometrial Receptivity. Therefore, individuals with a risk of infertility should pay attention to the consumption of Genistein and Daidzein.

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    APA: Copy

    Toktay, Erdem, SELLI, JALE, Gurbuz, Muhammed Ali, Tastan, Tugba Bal, Ugan, Rustem Anil, Un, Harun, & HALICI, ZEKAI. (2020). Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 23(12), 1603-1609. SID. https://sid.ir/paper/679573/en

    Vancouver: Copy

    Toktay Erdem, SELLI JALE, Gurbuz Muhammed Ali, Tastan Tugba Bal, Ugan Rustem Anil, Un Harun, HALICI ZEKAI. Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2020;23(12):1603-1609. Available from: https://sid.ir/paper/679573/en

    IEEE: Copy

    Erdem Toktay, JALE SELLI, Muhammed Ali Gurbuz, Tugba Bal Tastan, Rustem Anil Ugan, Harun Un, and ZEKAI HALICI, “Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 23, no. 12, pp. 1603–1609, 2020, [Online]. Available: https://sid.ir/paper/679573/en

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