The Well-Recognized Ability of Melatonin to Potentiate an Equilibrated Immune Response Calls for an Urgent Study about Its Use as an Adjuvant in Anti-SARS-Cov-2 Vaccines

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Maestroni Georges J.M.

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Journal Paper

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Journal: VACCINE RESEARCH Year:2020 | Volume:7 | Issue:2 Page(s): 97-100

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Title

The Well-Recognized Ability of Melatonin to Potentiate an Equilibrated Immune Response Calls for an Urgent Study about Its Use as an Adjuvant in Anti-SARS-Cov-2 Vaccines

Author(s)

Maestroni Georges J.M. | Issue Writer Certificate

Keywords

SARS-Cov-2

Melatonin

Immune Response

COVID-19 Vaccine

Abstract

Vaccines are a major weapon to control the present COVID-19 pandemic. To achieve this goal, vaccines should confer a robust and long-lasting immunity against SARS-Cov-2. Breakthrough infections and waning immunity are currently observed in patients that recovered from COVID-19 as well as in the vaccinated people. Therefore, a highly effective vaccine is needed to control the present and future outbreaks. Exogenous Nacetyl-5-methoxy-tryptamine or Melatonin (MLT) is well known to potentiate an effective and equilibrated Immune Response in a variety of situation including viral and bacterial infections and vaccines against different microbial and cancer antigens. In regard to anti-SARS-Cov-2 vaccines, beside stimulating specific IgG production as well as specific CD4+ and CD8+ T cells, exogenous MLT might also enhance specific IgA and secretory IgA in the mucosae; hence, preventing the re-infection and/or asymptomatic transmission of the virus. Thus, a study is urgently proposed to evaluate the effects of MLT administration either before or after vaccination against SARS-Cov-2 to evaluate its effect on strength, quality and duration of the immunity. Las but not least, due to its powerful antioxidant and anti-inflammatory properties, MLT administration might minimize the occurrence of adverse events after the vaccination.

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APA: Copy

Maestroni, Georges J.M.. (2020). The Well-Recognized Ability of Melatonin to Potentiate an Equilibrated Immune Response Calls for an Urgent Study about Its Use as an Adjuvant in Anti-SARS-Cov-2 Vaccines. VACCINE RESEARCH, 7(2), 97-100. SID. https://sid.ir/paper/679723/en

Vancouver: Copy

Maestroni Georges J.M.. The Well-Recognized Ability of Melatonin to Potentiate an Equilibrated Immune Response Calls for an Urgent Study about Its Use as an Adjuvant in Anti-SARS-Cov-2 Vaccines. VACCINE RESEARCH[Internet]. 2020;7(2):97-100. Available from: https://sid.ir/paper/679723/en

IEEE: Copy

Georges J.M. Maestroni, “The Well-Recognized Ability of Melatonin to Potentiate an Equilibrated Immune Response Calls for an Urgent Study about Its Use as an Adjuvant in Anti-SARS-Cov-2 Vaccines,” VACCINE RESEARCH, vol. 7, no. 2, pp. 97–100, 2020, [Online]. Available: https://sid.ir/paper/679723/en

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