miR-155, miR-21, and let-7a Expressions in MCF-10A and MCF-7 Cell Lines after Low to High Dose Irradiation

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Zare Afsaneh; FARDID REZA; Tamadon Gholam Hossein; MOSLEH SHIRAZI MOHAMMAD AMIN

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Journal Paper

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Journal: Cell Journal (Yakhteh) Year:2021 | Volume:23 | Issue:5 Page(s): 532-537

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Information Journal Paper

Title

miR-155, miR-21, and let-7a Expressions in MCF-10A and MCF-7 Cell Lines after Low to High Dose Irradiation

Author(s)

Zare Afsaneh | FARDID REZA | Tamadon Gholam Hossein | MOSLEH SHIRAZI MOHAMMAD AMIN | Issue Writer Certificate

Keywords

Breast Cancer

Ionizing Radiation

Let-7a

MiR-155

MiR-21

Abstract

that utilize cell pathways, which are implicated in human cancer prognosis. In addition, miRNAs respond to anti-cancer therapy and proliferation after irradiation. However, the changes in miRNA expression profiles in response to irradiation have not been comprehensively analysed. The present study was designed to assess potential changes that occur in miRNA expression following irradiation. Materials and Methods: In this experimental study, we used quantitative real-time polymerase chain reaction (qRTPCR) to measure the expressions of MiR-155, MiR-21, and Let-7a in MCF-10A (normal breast cells) and MCF-7 (Breast Cancer cells) six hours after the cells were exposed to five different irradiation doses (50, 100, 400, 2000, and 4000 mGY). Results: After irradiation from the low to high doses, we observed an upsurge in MiR-155 (more than 100%) expression and reduction in Let-7a (more than 87%) expression. However, there was an increase and a reduction in MiR-21 expression (more than 100%). Conclusion: Irradiation can play an important role in cancer development in normal breast cells (MCF-10A) at low dose irradiation. However, the results showed little difference at high doses of radiation.

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APA: Copy

Zare, Afsaneh, FARDID, REZA, Tamadon, Gholam Hossein, & MOSLEH SHIRAZI, MOHAMMAD AMIN. (2021). miR-155, miR-21, and let-7a Expressions in MCF-10A and MCF-7 Cell Lines after Low to High Dose Irradiation. CELL JOURNAL (YAKHTEH), 23(5), 532-537. SID. https://sid.ir/paper/679764/en

Vancouver: Copy

Zare Afsaneh, FARDID REZA, Tamadon Gholam Hossein, MOSLEH SHIRAZI MOHAMMAD AMIN. miR-155, miR-21, and let-7a Expressions in MCF-10A and MCF-7 Cell Lines after Low to High Dose Irradiation. CELL JOURNAL (YAKHTEH)[Internet]. 2021;23(5):532-537. Available from: https://sid.ir/paper/679764/en

IEEE: Copy

Afsaneh Zare, REZA FARDID, Gholam Hossein Tamadon, and MOHAMMAD AMIN MOSLEH SHIRAZI, “miR-155, miR-21, and let-7a Expressions in MCF-10A and MCF-7 Cell Lines after Low to High Dose Irradiation,” CELL JOURNAL (YAKHTEH), vol. 23, no. 5, pp. 532–537, 2021, [Online]. Available: https://sid.ir/paper/679764/en

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