INVOLVEMENT OF BRAIN‐DERIVED NEUROTROPHIC FACTOR (BDNF) ON MALATHION INDUCED DEPRESSIVE-LIKE BEHAVIOR IN SUBACUTE EXPOSURE AND PROTECTIVE EFFECTS OF CROCIN

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ARDEBILI DORRI SOMAYE; HOSSEINZADEH HOSSEIN; ABNOUS KHALIL; VAHDATI HASANI FAEZEH; YAZDIAN ROBATI REZVAN; RAZAVI BIBI MARJAN

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Journal: Iranian Journal of Basic Medical Sciences Year:2015 | Volume:18 | Issue:10 Page(s): 958-966

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Title

INVOLVEMENT OF BRAIN‐DERIVED NEUROTROPHIC FACTOR (BDNF) ON MALATHION INDUCED DEPRESSIVE-LIKE BEHAVIOR IN SUBACUTE EXPOSURE AND PROTECTIVE EFFECTS OF CROCIN

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Keywords

BDNF

CROCIN

DEPRESSION

FORCED SWIMMING TEST

MALATHION

SAFFRON

Abstract

Objective(s): In this study the effect of CROCIN, a carotenoid isolated from SAFFRON, on MALATHION (an organophosphate insecticide) induced depressive-like behavior in subacute exposure was investigated. Moreover the molecular mechanism of MALATHION induced depressive-like behavior and its decreasing effect on the level of brain derived neurotrophic factor (BDNF) in rat hippocampus and cerebral cortex were evaluated.Materials and Methods: Male Wistar rats were exposed to MALATHION (50 mg/kg/day, IP) alone or in combination with CROCIN (10, 20 and 40 mg/kg/day, IP), imipramine (20 mg/kg/day, IP) and vitamin E (200 mg/kg, three times a week, IP) respectively for 14 days. The FORCED SWIMMING TEST (FST) was performed on days 1st, 7th and 14st. The level of malondealdehyde (MDA) and reduced glutathione (GSH) were measured in cerebral cortex and hippocampus of rats. The protein level of BDNF was evaluated using Western blot analysis.Results: MALATHION (50 mg/kg, IP) increased immobility time in the FST, without affecting total locomotor activity in open‐field test. MALATHION increased the malondealdehyde (MDA) and decreased the glutathione (GSH), whereas these effects were reversed by CROCIN and vitamin E.Malathion decreased plasma acetylcholinesterase activity, however this effect was not reversed by CROCIN or vitamin E. MALATHION reduced the protein level of BDNF in rat hippocampus. Imipramine and CROCIN prevented the decreasing effect of MALATHION on BDNF.Conclusion: These results showed that CROCIN attenuates some neurochemical and behavioral effects induced by MALATHION. This neuroprotective effect of CROCIN may be in part due to its effect on BDNF.

Cites

The effects of crocin on spatial memory impairment induced by hyoscine: Role of NMDA, AMPA, ERK, and CaMKII proteins in rat hippocampus

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APA: Copy

ARDEBILI DORRI, SOMAYE, HOSSEINZADEH, HOSSEIN, ABNOUS, KHALIL, VAHDATI HASANI, FAEZEH, YAZDIAN ROBATI, REZVAN, & RAZAVI, BIBI MARJAN. (2015). INVOLVEMENT OF BRAIN?DERIVED NEUROTROPHIC FACTOR (BDNF) ON MALATHION INDUCED DEPRESSIVE-LIKE BEHAVIOR IN SUBACUTE EXPOSURE AND PROTECTIVE EFFECTS OF CROCIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(10), 958-966. SID. https://sid.ir/paper/680367/en

Vancouver: Copy

ARDEBILI DORRI SOMAYE, HOSSEINZADEH HOSSEIN, ABNOUS KHALIL, VAHDATI HASANI FAEZEH, YAZDIAN ROBATI REZVAN, RAZAVI BIBI MARJAN. INVOLVEMENT OF BRAIN?DERIVED NEUROTROPHIC FACTOR (BDNF) ON MALATHION INDUCED DEPRESSIVE-LIKE BEHAVIOR IN SUBACUTE EXPOSURE AND PROTECTIVE EFFECTS OF CROCIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(10):958-966. Available from: https://sid.ir/paper/680367/en

IEEE: Copy

SOMAYE ARDEBILI DORRI, HOSSEIN HOSSEINZADEH, KHALIL ABNOUS, FAEZEH VAHDATI HASANI, REZVAN YAZDIAN ROBATI, and BIBI MARJAN RAZAVI, “INVOLVEMENT OF BRAIN?DERIVED NEUROTROPHIC FACTOR (BDNF) ON MALATHION INDUCED DEPRESSIVE-LIKE BEHAVIOR IN SUBACUTE EXPOSURE AND PROTECTIVE EFFECTS OF CROCIN,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 10, pp. 958–966, 2015, [Online]. Available: https://sid.ir/paper/680367/en

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