The Potential of RNA Vaccines for Infectious Diseases and COVID-19

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Lundstrom Kenneth

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Journal Paper

Paper Information

Journal: VACCINE RESEARCH Year:2020 | Volume:7 | Issue:1 Page(s): 25-37

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Information Journal Paper

Title

The Potential of RNA Vaccines for Infectious Diseases and COVID-19

Author(s)

Lundstrom Kenneth | Issue Writer Certificate

Keywords

RNA vectors

RNA replicons

RNA vaccines

immune responses

protection against pathogens

coronaviruses

COVID-19

Abstract

In addition to conventional vaccine development for infectious diseases, nucleic acidbased vaccine approaches have recently been presented as serious alternatives to previously used strategies based on live attenuated virus particles and subunit vaccines. Particularly, RNA-based vaccines have proven attractive. In this context, immunization with messenger RNA (mRNA) has provided strong immune responses and protection against challenges with lethal doses of pathogenic viruses in vaccinated animals. Alternatively, the efficient RNA replication mechanism provided by self-amplifying RNA (saRNA) viruses has been utilized. Enhanced immune responses with reduced doses required for immunization has been obtained in comparison to conventional mRNA administration. The rapid spread and destruction caused by the COVID-19 pandemic has substantially accelerated the demand for the development of robust and efficient vaccines against SARS-CoV-2. Both mRNA-and saRNA-based COVID-19 vaccine candidates are currently in human clinical trials.

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References

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APA: Copy

Lundstrom, Kenneth. (2020). The Potential of RNA Vaccines for Infectious Diseases and COVID-19. VACCINE RESEARCH, 7(1), 25-37. SID. https://sid.ir/paper/680787/en

Vancouver: Copy

Lundstrom Kenneth. The Potential of RNA Vaccines for Infectious Diseases and COVID-19. VACCINE RESEARCH[Internet]. 2020;7(1):25-37. Available from: https://sid.ir/paper/680787/en

IEEE: Copy

Kenneth Lundstrom, “The Potential of RNA Vaccines for Infectious Diseases and COVID-19,” VACCINE RESEARCH, vol. 7, no. 1, pp. 25–37, 2020, [Online]. Available: https://sid.ir/paper/680787/en

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