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Information Journal Paper

Title

Anti-hyperglycemic, lipid-lowering, and anti-obesity effects of the triterpenes α and β-amyrenones in vivo

Pages

  451-463

Abstract

 Objective: Diabetes, Obesity, and their associated metabolic disorders are public health problems that require prevention and new efficient drugs for treatment. We evaluated the anti-hyperglycemic, lipid-lowering, and anti-Obesity effects of semisynthetic α , β-Amyrenones (ABA). Materials and Methods: BALB/c mice were used for performing an acute model of oral carbohydrate and triglyceride tolerance, and in a streptozotocin-induced Diabetes model, where Glycemia and body weight changes were measured during ten days. C57BL/6 strain mice were used in the diet-induced Obesity model, where lipidemia and body weight were measured during four weeks, and biochemical and histological parameters were analyzed after euthanasia. The doses considered in this study were 25, 50, and 100 mg/kg of ABA, used following some criteria for each experiment. Results: ABA 25 mg/kg reduced the postprandial Glycemia peak higher than acarbose 50 mg/kg (p<0. 05). ABA 50 mg/kg significantly reduced Glycemia in diabetic mice compared to acarbose 50 mg/kg (p<0. 05). There was a reduction in the weight of the obese animals treated with ABA 25 and 50 mg/kg (p<0. 05). ABA 50 mg/kg also significantly reduced lipidemia in these animals compared to orlistat 50 mg/kg. Conclusion: This study presents evidence of ABA's action in reducing postprandial Glycemia and Obesity in mice.

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    APA: Copy

    da Silva Ferreira, Rosilene Gomes, Guilhon Simplicio, Fernanda, Rosales Acho, Leonard Domingo, Batista, Nayana Yared, Guedes Junior, Frank do Carmo, Leao Ferreira, Mayla Silva, Marques Barcellos, Jose Fernando, Veiga Junior, Valdir Florencio, & Lima, Emerson Silva. (2021). Anti-hyperglycemic, lipid-lowering, and anti-obesity effects of the triterpenes α and β-amyrenones in vivo. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 11(5), 451-463. SID. https://sid.ir/paper/681872/en

    Vancouver: Copy

    da Silva Ferreira Rosilene Gomes, Guilhon Simplicio Fernanda, Rosales Acho Leonard Domingo, Batista Nayana Yared, Guedes Junior Frank do Carmo, Leao Ferreira Mayla Silva, Marques Barcellos Jose Fernando, Veiga Junior Valdir Florencio, Lima Emerson Silva. Anti-hyperglycemic, lipid-lowering, and anti-obesity effects of the triterpenes α and β-amyrenones in vivo. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2021;11(5):451-463. Available from: https://sid.ir/paper/681872/en

    IEEE: Copy

    Rosilene Gomes da Silva Ferreira, Fernanda Guilhon Simplicio, Leonard Domingo Rosales Acho, Nayana Yared Batista, Frank do Carmo Guedes Junior, Mayla Silva Leao Ferreira, Jose Fernando Marques Barcellos, Valdir Florencio Veiga Junior, and Emerson Silva Lima, “Anti-hyperglycemic, lipid-lowering, and anti-obesity effects of the triterpenes α and β-amyrenones in vivo,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 11, no. 5, pp. 451–463, 2021, [Online]. Available: https://sid.ir/paper/681872/en

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