مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

111
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

95
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

A comparison between the effect of trans-anethole and metformin on biochemical parameters of polycystic ovary syndrome in rats

Pages

  484-493

Abstract

 Objective: The effect of Trans-anethole and Metformin on biochemical and hormonal changes of Testosterone-induced Polycystic ovary syndrome (PCOS) in rats was investigated. Materials and Methods: Female Wister rats (n=48) were randomly divided into six groups: control; PCOS; PCOS+Metformin (300 mg/kg); and PCOS+Trans-anethole (20, 40, and 80 mg/kg). PCOS was induced by intraperitoneal injection of Testosterone (1 mg/kg/day) for 35 days. After induction of PCOS, Trans-anethole and Metformin were given orally for 30 days. Finally, blood sugar, Insulin, lipid profile, and Testosterone and Dehydroepiandrosterone (DHEAS) as well as animals’ weight, and water and food intake were determined. Results: In all treated and untreated PCOS groups, serum Testosterone levels were significantly increased compared to the control group (p<0. 001 for all groups). Treatment of rats with Trans-anethole or Metformin significantly reduced serum levels of cholesterol, Insulin, triglycerides, Testosterone and DHEAS (only in PCOS+Trans-anethole groups) compared to the PCOS group (p<0. 01-p<0. 001). Weight gain in the PCOS animals increased significantly compared to the control group (p<0. 001), while in the Metformin-and Trans-anethole (40 and 80)-treated animals it decreased significantly compared to the PCOS group (p<0. 01-p<0. 001). Conclusion: These results showed that Trans-anethole significantly decreased serum levels of Insulin, DHEAS and blood lipids. It can be concluded that Trans-anethole ameliorates PCOS biochemical and hormonal change in PCOS rats; therefore, it might be suggested as a beneficial remedy for further clinical evaluations in PCOS patients.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Moradi Negahdari, Faezeh, HADJZADEH, MOUSA AL REZA, GHOLAMNEZHAD, ZAHRA, SAMADI NOSHAHR, ZAHRA, & KESHAVARZI, ZAKIEH. (2021). A comparison between the effect of trans-anethole and metformin on biochemical parameters of polycystic ovary syndrome in rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 11(5), 484-493. SID. https://sid.ir/paper/681874/en

    Vancouver: Copy

    Moradi Negahdari Faezeh, HADJZADEH MOUSA AL REZA, GHOLAMNEZHAD ZAHRA, SAMADI NOSHAHR ZAHRA, KESHAVARZI ZAKIEH. A comparison between the effect of trans-anethole and metformin on biochemical parameters of polycystic ovary syndrome in rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2021;11(5):484-493. Available from: https://sid.ir/paper/681874/en

    IEEE: Copy

    Faezeh Moradi Negahdari, MOUSA AL REZA HADJZADEH, ZAHRA GHOLAMNEZHAD, ZAHRA SAMADI NOSHAHR, and ZAKIEH KESHAVARZI, “A comparison between the effect of trans-anethole and metformin on biochemical parameters of polycystic ovary syndrome in rats,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 11, no. 5, pp. 484–493, 2021, [Online]. Available: https://sid.ir/paper/681874/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button