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Title

BRAIN-DERIVED NEUROTROPHIC AND IMMUNOLOGIC FACTORS: BENEFICIAL EFFECTS OF RIBOFLAVIN ON MOTOR DISABILITY IN MURINE MODEL OF MULTIPLE SCLEROSIS

Pages

  439-448

Abstract

 Objective (s): In the present study, C57BL/6 female mice (n=56) were used to explore the neuroprotective effects of riboflavin in motor disability of experimental autoimmune encephalomyelitis (EAE) as a model of multiple sclerosis.Materials and Methods: The animals were assigned into 7 groups: sham-operated 1 (SO1), healthy mice receiving PBS (phosphate buffer saline); sham-operated 2 (SO2), healthy mice receiving PBS and riboflavin; sham treatment 1 (ST1), EAE mice receiving water; sham treatment 2 (ST2), EAE mice receiving sodium acetate buffer; treatment 1 (T1), EAE mice receiving interferon beta-1a (INFβ-1a); treatment 2 (T2), EAE mice receiving riboflavin; treatment 3 (T3), EAE mice receiving INFβ-1a and riboflavin. After EAE induction, scoring was performed based on clinical signs. Upon detecting score 0.5, riboflavin at 10 mg/kg of body weight and/or INFβ-1a at 150 IU/g of body weight administration was started for two weeks. The brain and spinal cord levels of brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), and interleukin-17A (IL-17A) were studied using real-time PCR and ELISA methods.Results: BDNF expression and protein levels were increased in the brain and spinal cord of the T3 group compared with the other groups (P<0.01). IL-6 and IL-17A expressions were increased in the brains of the T3 and T1 groups, respectively, compared to the other groups (P<0.01). The daily clinical score was reduced significantly by riboflavin in both effector and chronic phases of the disease compared with that of the controls (P<0.05).Conclusion: Our findings showed that riboflavin is capable of suppressing the neurological disability mediated by BDNF and IL-6.

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    APA: Copy

    NAGHASHPOUR, MAHSHID, ZAMANI, REZA, SARKAKI, ALIREZA, GHADIRI, ATA, SAMARBAFZADEH, ALIREZA, JAFARIRAD, SIMA, & SAKI MALEHI, AMAL. (2016). BRAIN-DERIVED NEUROTROPHIC AND IMMUNOLOGIC FACTORS: BENEFICIAL EFFECTS OF RIBOFLAVIN ON MOTOR DISABILITY IN MURINE MODEL OF MULTIPLE SCLEROSIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(4), 439-448. SID. https://sid.ir/paper/683549/en

    Vancouver: Copy

    NAGHASHPOUR MAHSHID, ZAMANI REZA, SARKAKI ALIREZA, GHADIRI ATA, SAMARBAFZADEH ALIREZA, JAFARIRAD SIMA, SAKI MALEHI AMAL. BRAIN-DERIVED NEUROTROPHIC AND IMMUNOLOGIC FACTORS: BENEFICIAL EFFECTS OF RIBOFLAVIN ON MOTOR DISABILITY IN MURINE MODEL OF MULTIPLE SCLEROSIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(4):439-448. Available from: https://sid.ir/paper/683549/en

    IEEE: Copy

    MAHSHID NAGHASHPOUR, REZA ZAMANI, ALIREZA SARKAKI, ATA GHADIRI, ALIREZA SAMARBAFZADEH, SIMA JAFARIRAD, and AMAL SAKI MALEHI, “BRAIN-DERIVED NEUROTROPHIC AND IMMUNOLOGIC FACTORS: BENEFICIAL EFFECTS OF RIBOFLAVIN ON MOTOR DISABILITY IN MURINE MODEL OF MULTIPLE SCLEROSIS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 4, pp. 439–448, 2016, [Online]. Available: https://sid.ir/paper/683549/en

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