مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ACTIVE COMPONENTS OF FUNGUSSHIRAIA BAMBUSISCOLA CAN SPECIFICALLY INDUCE BGC823 GASTRIC CANCER CELL APOPTOSIS

Pages

  149-158

Abstract

 Objective: GASTRIC CANCER is a major health issue worldwide. Using a therapeutic approach, with minor side-effects, is very essential for the treatment of the GASTRIC CANCER.SHIRAIA BAMBUSICOLAis a parasitic fungus which is widely used in China for curing several diseases with little side-effects. However, the mechanisms are not well understood yet.The aim of this study was to further understand the pharmacological mechanisms ofSHIRAIA BAMBUSICOLAand investigate whether it can be used for curing GASTRIC CANCER.Materials and Methods: In this experimental study, we mainly tested the effect of active components extracted fromSHIRAIA BAMBUSICOLA on BGC823, A549 and HepG2 cells. We used MTT assay to test cell viability. We also analyzed morphologic changes caused by APOPTOSIS using Hoechst 33342 fluorescence staining, as well as cell cycle status and APOPTOSIS ratio using flow-cytometer. In addition, protein expression level was tested by Western-blotting assay.Results: BGC-823 cell proliferation was specifically inhibited by active components of SHIRAIA BAMBUSICOLA. Meanwhile, these active components could induce BGC-823 cells APOPTOSIS and retard the cell cycle in S/G2 phase. We also determined that two critical protein markers cleaved Poly (ADP-ribose) polymerase-1 (PARP-1) and FLICE-inhibitory protein (FLIP), involved in APOPTOSIS process, were regulated by these active components.Conclusion: These data shed light on the treatment of human GASTRIC CANCER and conclude thatSHIRAIA BAMBUSICOLA can be a good therapeutic candidate for treatment of this malignancy.

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    APA: Copy

    ZHANG, SHUBING, QIU, DEWEN, LIU, JINGJIANG, & LI, ZHIJIAN. (2016). ACTIVE COMPONENTS OF FUNGUSSHIRAIA BAMBUSISCOLA CAN SPECIFICALLY INDUCE BGC823 GASTRIC CANCER CELL APOPTOSIS. CELL JOURNAL (YAKHTEH), 18(2 (70)), 149-158. SID. https://sid.ir/paper/683559/en

    Vancouver: Copy

    ZHANG SHUBING, QIU DEWEN, LIU JINGJIANG, LI ZHIJIAN. ACTIVE COMPONENTS OF FUNGUSSHIRAIA BAMBUSISCOLA CAN SPECIFICALLY INDUCE BGC823 GASTRIC CANCER CELL APOPTOSIS. CELL JOURNAL (YAKHTEH)[Internet]. 2016;18(2 (70)):149-158. Available from: https://sid.ir/paper/683559/en

    IEEE: Copy

    SHUBING ZHANG, DEWEN QIU, JINGJIANG LIU, and ZHIJIAN LI, “ACTIVE COMPONENTS OF FUNGUSSHIRAIA BAMBUSISCOLA CAN SPECIFICALLY INDUCE BGC823 GASTRIC CANCER CELL APOPTOSIS,” CELL JOURNAL (YAKHTEH), vol. 18, no. 2 (70), pp. 149–158, 2016, [Online]. Available: https://sid.ir/paper/683559/en

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