PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ACTIVITY IS REQUIRED FOR APPROPRIATE CARDIOMYOCYTE DIFFERENTIATION

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PEYMANI MARYAM; GHAEDI KAMRAN; IRANI SHIVA; NASR ESFAHANI MOHAMMAD HOSSEIN

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Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2016 | Volume:18 | Issue:2 (70) Page(s): 221-228

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Title

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ACTIVITY IS REQUIRED FOR APPROPRIATE CARDIOMYOCYTE DIFFERENTIATION

Author(s)

PEYMANI MARYAM | GHAEDI KAMRAN | IRANI SHIVA | NASR ESFAHANI MOHAMMAD HOSSEIN | Issue Writer Certificate

Keywords

EMBRYONIC STEM CELL

PPARγ

DIFFERENTIATION

Abstract

Objective: Peroxisome proliferator-activated receptor γ (PPARg) is a member of the PPAR nuclear receptor superfamily. Although PPARg acts as a master transcription factor in adipocyte DIFFERENTIATION, it is also associated with a variety of cell functions including carbohydrate and lipid metabolism, glucose homeostasis, cell proliferation and cell DIFFERENTIATION.This study aimed to assess the expression level of PPARg in order to address its role in cardiac cell DIFFERENTIATION of mouse EMBRYONIC STEM CELLs (mESCs).Materials and Methods: In this an intervening study, mESCs were subjected to cardiac DIFFERENTIATION.Total RNA was extracted from the cells and quantitative real time polymerase chain reaction (qPCR) was carried out to estimate level of gene expression. Furthermore, the requirement of PPARg in cardiac DIFFERENTIATION of mESCs, during cardiac progenitor cells (CPCs) formation, was examined by applying the respective agonist and antagonist.Results: The obtained data revealed an elevation in the expression level of PPARg during spontaneous formation of CPCs and cardiomyocytes. Our results indicated that during CPC formation, PPARg inactivation via treatment with GW9662 (GW) reduced expression of CPC and cardiac markers.Conclusion: We conclude that PPARγ modulation has an effective role on cardiac DIFFERENTIATION of mESCs at the early stage of cardiomyogenesis.

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APA: Copy

PEYMANI, MARYAM, GHAEDI, KAMRAN, IRANI, SHIVA, & NASR ESFAHANI, MOHAMMAD HOSSEIN. (2016). PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ACTIVITY IS REQUIRED FOR APPROPRIATE CARDIOMYOCYTE DIFFERENTIATION. CELL JOURNAL (YAKHTEH), 18(2 (70)), 221-228. SID. https://sid.ir/paper/683562/en

Vancouver: Copy

PEYMANI MARYAM, GHAEDI KAMRAN, IRANI SHIVA, NASR ESFAHANI MOHAMMAD HOSSEIN. PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ACTIVITY IS REQUIRED FOR APPROPRIATE CARDIOMYOCYTE DIFFERENTIATION. CELL JOURNAL (YAKHTEH)[Internet]. 2016;18(2 (70)):221-228. Available from: https://sid.ir/paper/683562/en

IEEE: Copy

MARYAM PEYMANI, KAMRAN GHAEDI, SHIVA IRANI, and MOHAMMAD HOSSEIN NASR ESFAHANI, “PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ACTIVITY IS REQUIRED FOR APPROPRIATE CARDIOMYOCYTE DIFFERENTIATION,” CELL JOURNAL (YAKHTEH), vol. 18, no. 2 (70), pp. 221–228, 2016, [Online]. Available: https://sid.ir/paper/683562/en

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