P63 AND KI-67 EXPRESSION IN DENTIGEROUS CYST AND AMELOBLASTOMAS

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JAAFARI ASHKAVANDI ZOHREH; GERAMIZADEH BITA; RANJBAR MOHAMMAD ALI

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Paper Information

Journal: JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES) Year:2015 | Volume:16 | Issue:4 Page(s): 323-328

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Title

P63 AND KI-67 EXPRESSION IN DENTIGEROUS CYST AND AMELOBLASTOMAS

Author(s)

JAAFARI ASHKAVANDI ZOHREH | GERAMIZADEH BITA | RANJBAR MOHAMMAD ALI | Issue Writer Certificate

Keywords

P63

KI-67

DENTIGEROUS CYST

AMELOBLASTOMA

UNICYSTIC AMELOBLASTOMA

Abstract

Statement of the Problem: P63 gene is a member of TP53 and its homologous gene family. Its expression was observed in some odontogenic lesions, more expression in aggressive lesions.Purpose: This study aimed to investigate the possible diagnostic impact of P63 protein on DENTIGEROUS CYSTs and various types of AMELOBLASTOMA. Its expression with KI-67 proliferation marker was also compared.Materials and Method: This cross-sectional retrospective study was enrolled on 25 cases of DENTIGEROUS CYST including 21 unicystic AMELOBLASTOMAs and 17 conventional AMELOBLASTOMAs. The expression of P63 and KI-67 was assessed by immunohistochemical (IHC) examinations. Data were analyzed by employing Mann-Whitney and correlation coefficient tests.Results: P63 expression was significantly higher in AMELOBLASTOMA than unicystic AMELOBLASTOMA and DENTIGEROUS CYSTs. There was no significant difference between unicystic AMELOBLASTOMA and DENTIGEROUS CYST in P63 expression. A 90% cut-off point was obtained for basal layer which gave 88% sensitivity and 78% specificity to distinguish more invasive lesions from others. There was not any correlation between P63 and KI-67 immunostaining in the three study groups.Conclusion: More aggressiveness and more invasiveness of odontogenic lesions depicted higher rate and also more intensive expression of P63. Moreover, the expression of P63 protein had not any correlation with KI-67 protein in DENTIGEROUS CYSTs and AMELOBLASTOMAs.

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APA: Copy

JAAFARI ASHKAVANDI, ZOHREH, GERAMIZADEH, BITA, & RANJBAR, MOHAMMAD ALI. (2015). P63 AND KI-67 EXPRESSION IN DENTIGEROUS CYST AND AMELOBLASTOMAS. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 16(4), 323-328. SID. https://sid.ir/paper/684292/en

Vancouver: Copy

JAAFARI ASHKAVANDI ZOHREH, GERAMIZADEH BITA, RANJBAR MOHAMMAD ALI. P63 AND KI-67 EXPRESSION IN DENTIGEROUS CYST AND AMELOBLASTOMAS. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2015;16(4):323-328. Available from: https://sid.ir/paper/684292/en

IEEE: Copy

ZOHREH JAAFARI ASHKAVANDI, BITA GERAMIZADEH, and MOHAMMAD ALI RANJBAR, “P63 AND KI-67 EXPRESSION IN DENTIGEROUS CYST AND AMELOBLASTOMAS,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 16, no. 4, pp. 323–328, 2015, [Online]. Available: https://sid.ir/paper/684292/en

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